Interaction between hepatitis C virus and lipoproteins and its role for infection and viral persistence (A06)

50%至90%的丙型肝炎病毒（HCV）感染呈慢性病程。病毒与脂蛋白的关联可能通过对病毒进入肝细胞的直接影响以及另外通过对抗体的保护而有助于持久性。载脂蛋白E （ApoE）多态性与HCV感染的不同过程有关。因此，我们阐明了介导HCV脂蛋白相互作用的机制，我们剖析了病毒相关脂蛋白在HCV细胞进入中的作用，我们研究了HCV脂蛋白相互作用在体内的变异性。这些目标旨在分析介导脂蛋白关联的病毒和宿主因子，并确定它们在病毒持久性中的作用。

Fifty to 90% of hepatitis C virus (HCV) infections take a chronic course. The association of the virus with lipoproteins may contribute to persistence via a direct influence on virus entry into liver cells and in addition through protection from antibodies. Apolipoprotein E (ApoE) polymorphisms are associated with a different course of HCV infection. Therefore, we elucidate the mechanisms that mediate HCV lipoprotein interaction, we dissect the role of virus-associated lipoproteins for HCV cell entry and we investigate the variability of HCV lipoprotein interaction in vivo. These goals aim at analysing viral and host factors that mediate association with lipoproteins and to define their role for virus persistence.