SBIR Phase I: Molecular Design of Advanced Monolayers For Improved Surface Amination

这个小企业创新研究（SBIR）第一阶段项目旨在满足特定表面功能的高级单分子层竞技场的需求。该项目解决了阻碍许多新型生物传感器、实验室芯片和BioMEMS进入市场的关键限制因素，即用于将生物分子耦合到界面的化学物质。 氨丙基三甲氧基硅烷（APTMS）是当今最常用的连接化学品，它被用于各种各样的应用，从色谱柱中的固定相，到DNA实验室芯片，再到化学传感器。 然而，对这种分子（及其形成的分子层）的控制和操纵仍然不足和有限。 目前的建议，旨在达到新的合成路线的胺封端的分子层来自新的前体。 这反过来又可能导致下一代先进传感器、生物测定设备、DNA芯片和其他医疗诊断/治疗技术的发展。

This Small Business Innovation Research (SBIR) Phase I project seeks to fill a need in the arena of advanced monomolecular layers for specific surface functionalities. The project addresses a key limiting factor which prevents many novel biosensors, labchips and BioMEMS from reaching the market, i.e. the chemistry used for coupling biomolecules to interfaces. Aminopropyltrimethoxysilane (APTMS) is the most commonly used linking chemistry today, and it is being used in a wide variety of applications from stationary phases in chromatographic columns, to DNA labchips, to chemical sensors. The control and manipulation of this molecule (and molecular layer(s) it forms), however, remains insufficient and limited. The current proposal aims to arrive at new synthetic routes for amine-terminated molecular layers derived from novel precursors. This could, in turn, lead to the development of next-generation advanced sensors, bioassay devices, DNA chips and other medical diagnostic/therapeutic technologies.