SBIR Phase I: Molecular Design of Advanced Monolayers For Improved Surface Amination

SBIR 第一阶段：先进单分子层的分子设计以改善表面胺化

• 批准号: 0638251
• 负责人: Jeffrey Chinn
• 金额: $ 10万
• 依托单位: Applied MicroStructures, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0638251&HistoricalAwards=false
• 关键词: SBIR; Phase; Molecular; Design; Advanced

This Small Business Innovation Research (SBIR) Phase I project seeks to fill a need in the arena of advanced monomolecular layers for specific surface functionalities. The project addresses a key limiting factor which prevents many novel biosensors, labchips and BioMEMS from reaching the market, i.e. the chemistry used for coupling biomolecules to interfaces. Aminopropyltrimethoxysilane (APTMS) is the most commonly used linking chemistry today, and it is being used in a wide variety of applications from stationary phases in chromatographic columns, to DNA labchips, to chemical sensors. The control and manipulation of this molecule (and molecular layer(s) it forms), however, remains insufficient and limited. The current proposal aims to arrive at new synthetic routes for amine-terminated molecular layers derived from novel precursors. This could, in turn, lead to the development of next-generation advanced sensors, bioassay devices, DNA chips and other medical diagnostic/therapeutic technologies.

这项小型企业创新研究（SBIR）第一阶段项目旨在填补先进单分子层在特定表面功能领域的需求。该项目解决了阻碍许多新型生物传感器、labchips和BioMEMS进入市场的关键限制因素，即用于将生物分子偶联到界面的化学物质。氨丙基三甲氧基硅烷（APTMS）是当今最常用的连接化学，它被用于各种各样的应用，从色谱柱的固定相，到DNA标签芯片，到化学传感器。然而，对这种分子（及其形成的分子层）的控制和操纵仍然是不充分和有限的。目前的建议旨在到达新的合成路线胺端分子层源自新的前体。反过来，这可能导致下一代先进传感器、生物测定装置、DNA芯片和其他医疗诊断/治疗技术的发展。