CAREER: Versatile Vanadium: Materials Science, Biology, and Education Through Its Diverse Coordination Chemistry

这项由无机化学、生物无机化学和金属有机化学项目颁发的职业奖支持伊利诺伊州立大学的Craig C.McLauchlan博士关于钒与三齿蝎酸盐配体的配位化学和反应性的研究。这些研究将阐明制备这些配位络合物的合成方法，并检查它们的反应性和性能，用于材料、催化和治疗医学应用。建议的研究将揭示新的钒-有机膦络合物，并提供通过配体选择来控制维度的洞察力。拟议的工作通过扩大对这些络合物在生理条件下主要氧化态的个别因素的理解，为将钒络合物用作药物治疗剂提供了更多的见解。这个项目的教育部分包括为一系列逐步复杂的课程创建教育模块，这些课程涉及到学生反应装置(又名：“点击器”)技术。McLauchlan教授还将加入模型工具包，用于提高学生对分子级结构的理解。他将建立一个指导网络，并为感兴趣的社区学院教职员工提供研讨会和免费使用学生回应系统。McLauchlan教授还将在教学/研究实验室指导学生，为他们提供合成、表征和X射线培训方面的广泛技能，这将为学生在工业或研究生院的未来做好准备。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports research by Dr. Craig C. McLauchlan at Illinois State University on the coordination chemistry and reactivity of vanadium with tridentate scorpionate ligands. The studies will elucidate synthetic methodologies in the preparation of these coordination complexes and examine their reactivities and properties for use in materials, catalysis, and therapeutic medicinal applications. The proposed studies should reveal novel vanadium-organophosphonate complexes and offer insight in control of dimensionality through ligand choice. The proposed work offers additional insight into the utilization of vanadium complexes as medicinal therapeutic agents by expanding the understanding of individual factors in the dominant oxidation states of these complexes under physiological conditions. The educational component of this project involves the creation of educational modules for a series of progressively complex classes on the subject of coordination chemistry involving Student Response Device (a.k.a. "clicker") technology. Professor McLauchlan will also incorporate model kits for use in improving student understanding of molecular-level structure. He will establish a mentoring network and offer workshops and free use of a student response system to interested community college faculty. Professor McLauchlan will also mentor students in the teaching/research laboratory, providing them with a broad skill set in synthesis, characterization, and X-ray training, which will prepare the students well for their futures in industry or graduate school.