Analysis of the role of the shedding protease ADAM 17 in vivo (A01)

ADAM17是IL-6R、TNFα和EGF受体（EGF- r）配体等底物的主要脱落蛋白酶。ADAM17在动脉粥样硬化和中风动物模型中具有保护作用。相反，ADAM17缺乏可防止肾纤维化和肠道肿瘤发生。在下一个资助期，将研究ADAM17在自身炎症模型中的作用，以了解ADAM17- egf - r - il -6轴的激活如何促进自身免疫性疾病，以及阻断ADAM17是否可以用于治疗。

ADAM17 is the major shedding protease for substrates such as IL-6R, TNFα and ligands of the EGF receptor (EGF-R). ADAM17 is protective in animal models of atherosclerosis and stroke. In contrast, ADAM17 deficiency prevented kidney fibrosis and intestinal tumorigenesis. In the next funding period, the role of ADAM17 in auto-inflammatory models will be studied to understand how the activation of the ADAM17-EGF-R-IL-6 axis contributes to autoimmune diseases in general and whether blocking ADAM17 can be exploited therapeutically.