The cisGRN Browser and Database: cis-Regulatory Information Behind the Network

cisGRN 浏览器和数据库：网络背后的 cis 监管信息

• 批准号: 0645955
• 负责人: Sorin Istrail
• 金额: $ 85万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645955&HistoricalAwards=false
• 关键词: cisGRN; Browser; Database; cis; Regulatory

Brown University is awarded a grant to develop algorithms and software tools for building genomic maps of the developmental regulatory circuitry of cells. The focus is on two fundamental problems of great practical importance. The first is to build the cisGRN Database of genomic regulatory information behind gene networks: capturing the complex nature of the cis-regulatory evidence from many kinds of regulatory information across technologies. The database will contain the following components: genomic structure and organization, comparative genomics, cis-regulatory analysis of expressions constructs and mutational analysis, spatial expression profiles, and logic functions of the genomic cis-regulatory code. The second aim is to build Regulatory Genomics Logic Map Browser a next-generation genome browser incorporating model-building, annotation, and visualization capabilities for gene regulatory systems and networks. It will present genomic structural views, spatial expression views, expression constructs views, and information processing views, obtained through mathematical analysis of the logical principles of genomic regulatory systems and networks. The work will be carried out in collaboration with the California Institute of Technology.

布朗大学获得了一笔赠款，用于开发用于构建细胞发育调控电路基因组图谱的算法和软件工具。重点是两个具有重大实际意义的基本问题。首先是建立基因网络背后的基因组调控信息的cisGRN数据库：从跨技术的多种调控信息中捕获顺式调控证据的复杂性。该数据库将包含以下组成部分：基因组结构和组织，比较基因组学，表达构建体和突变分析的顺式调控分析，空间表达谱，以及基因组顺式调控密码的逻辑功能。第二个目标是建立监管基因组学逻辑地图浏览器，一个新一代的基因组浏览器，结合模型构建，注释和可视化功能的基因调控系统和网络。它将提出基因组结构视图，空间表达视图，表达构建视图和信息处理视图，通过对基因组调控系统和网络的逻辑原理进行数学分析获得。这项工作将与加州理工学院合作进行。