The cisGRN Browser and Database: cis-Regulatory Information Behind the Network

布朗大学获得了一笔拨款，用于开发算法和软件工具，以构建细胞发育调节回路的基因组图谱。重点是两个具有重大现实意义的根本问题。首先是建立基因网络背后的基因组调控信息的cisGRN数据库：从多种不同技术的调控信息中获取顺式调控证据的复杂性。该数据库将包含以下组成部分：基因组结构和组织、比较基因组学、表达结构的顺式调控分析和突变分析、空间表达谱和基因组顺式调控代码的逻辑功能。第二个目标是构建调控基因组学逻辑地图浏览器，这是下一代基因组浏览器，结合了基因调控系统和网络的模型构建、注释和可视化功能。它将通过对基因组调控系统和网络的逻辑原理的数学分析获得基因组结构视图、空间表达视图、表达构造视图和信息处理视图。这项工作将与加州理工学院合作进行。

Brown University is awarded a grant to develop algorithms and software tools for building genomic maps of the developmental regulatory circuitry of cells. The focus is on two fundamental problems of great practical importance. The first is to build the cisGRN Database of genomic regulatory information behind gene networks: capturing the complex nature of the cis-regulatory evidence from many kinds of regulatory information across technologies. The database will contain the following components: genomic structure and organization, comparative genomics, cis-regulatory analysis of expressions constructs and mutational analysis, spatial expression profiles, and logic functions of the genomic cis-regulatory code. The second aim is to build Regulatory Genomics Logic Map Browser a next-generation genome browser incorporating model-building, annotation, and visualization capabilities for gene regulatory systems and networks. It will present genomic structural views, spatial expression views, expression constructs views, and information processing views, obtained through mathematical analysis of the logical principles of genomic regulatory systems and networks. The work will be carried out in collaboration with the California Institute of Technology.