US-Japan Seminar in Marine Natural Products Research

海洋大型生物仍然是非常丰富的生物活性代谢物来源，一些在生物医学中有用，另一些作为工具化合物或药理探针具有价值。虽然化学合成仍然是生产类似物的最佳方法之一，也是深入生物测试所需数量的新化合物，但天然产物化学和合成有机化学的有效结合相当稀缺，这两个学科的个人之间的联系也不是最优的。此次研讨会将为美国和日本的合成化学家在海洋天然产品和其他海洋天然产品研究人员之间建立新的合作提供场所。凭借这一奖项，国际科学与工程办公室和有机与高分子化学计划将支持将于2007年7月1日至6日在犹他州帕克城举行的美日海洋天然产品研究研讨会。该研讨会由犹他大学药物化学系的克里斯·M·爱尔兰教授组织，目的是在广泛的主题上交流信息并探索未来的前景。计划为这次会议规划的主题是：(A)作为化学多样性独特来源的海洋衍生微型和大型生物；(B)海洋微型和大型生物的生物医学潜力；(C)作为分子生物学和生物技术工具的海洋天然产品；(D)次级代谢物介导的物种间相互作用；(E)经典和分子遗传方法研究的海洋生物合成；(F)具有重要生物医学意义的海洋代谢物的化学合成和性质。这些主题将提供探索各种基本主题以及新兴新技术的机会。这次研讨会的形式将强调介绍和讨论将作为这一领域未来研究的基础的想法，并必然会促进在这些重要生物医学主题上的新的双边合作。参与者名单包括来自主要学术、工业和政府实验室的代表，并提供了现有研究人员、职业生涯早期阶段的个人、少数族裔和女性的平衡。

Marine macroorganisms continue to be an extraordinarily rich source of bioactive metabolites, some with utility in biomedicine, and others with value as tool compounds or pharmacological probes. While chemical synthesis continues to be one of the best methods for the production of analogs as well as needed quantities of a new compound for in depth biological testing, the effective integration of natural products chemistry and synthetic organic chemistry is quite scarce and the connections between individuals from these two disciplines is not optimal. This workshop will provide a venue for establishing new collaborations between synthetic chemists in the US and Japan focusing on marine natural products and other marine natural products researchers.With this award, the Office of International Science and Engineering and the Organic and Macromolecular Chemistry Program are supporting a US-Japan Seminar on Marine Natural Products Research, to be held In Park City, Utah on July 1-6, 2007. The objective of the workshop, organized by Professor Chris M. Ireland, of the Department of Medicinal Chemistry at the University of Utah, is to exchange information and explore future prospects on a broad range of topics. Themes planned for the meeting are: (a) marine-derived micro and macro organisms as unique sources of chemical diversity; (b) biomedical potential of marine micro and macro organisms; (c) marine natural products as tools in molecular biology and biotechnology; (d) interactions between species mediated by secondary metabolites; (e) marine biosynthesis studied by classical as well as molecular genetic methodologies, and (f) chemical synthesis and properties of biomedically important marine metabolites. These topics will provide opportunities to explore a variety of fundamental subjects along with emerging new techniques. The format for this workshop will emphasize the presentation and discussion of ideas which will underlie future research to be conducted in this field, and will necessarily stimulate new bilateral collaborations on these important biomedical topics. The list of participants includes representatives from major academic, industrial, and government laboratories, and provides a balance of established investigators, individuals at early stages of their careers, minorities and women.