Modeling and Control in Cancer Genomics

癌症基因组学的建模和控制

• 批准号: 0701531
• 负责人: Aniruddha Datta
• 金额: $ 27万
• 依托单位: Texas A&M Engineering Experiment Station
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0701531&HistoricalAwards=false
• 关键词: Modeling; Control; Cancer; Genomics

Intellectual Merit: The aim of this project is to use and adapt ideas from Control Theory to develop improved methods for treating cancer. The disease originates from aberrant gene functioning at the molecular level and, therefore, it is crucial that techniques for diagnosing and treating cancers take the genetic differences between individuals into account. Unfortunately, the currently used therapies for cancer are of the one-size-fits-all type and, therefore, it is not surprising that their success rate is quite low and unpredictable. This project will examine the possibility of remedying this situation. The researchers and their collaborators have already obtained substantial theoretical results on the related problems, and validation experiments are currently under way. This project will address the many theoretical challenges that will arise as the experiments progress over the next two to three years. Broader Impacts: The results of the research resulting from this project will be disseminated to the community by organizing conferences, workshops and short courses. We will go the extra mile to ensure that the benefits of our research and educational activities reach underrepresented minorities by (i) making our genomics courses available to minority institutions; (ii) actively collaborating with researchers there; and (iii) recruiting more women and minority students into our laboratory. Our current efforts in these directions will be kept at the same level, if not further intensified. The most significant long term impact of our work would be to replace existing one-size-fits-all cancer therapies with individually customized and better ones derived from engineering approaches.

智力优势：该项目的目的是使用和适应控制理论的思想，以开发治疗癌症的改进方法。 这种疾病起源于分子水平上的异常基因功能，因此，诊断和治疗癌症的技术必须考虑到个体之间的遗传差异。不幸的是，目前使用的癌症治疗方法都是一刀切的，因此，它们的成功率非常低且不可预测也就不足为奇了。本项目将研究纠正这种情况的可能性。研究人员及其合作者已经在相关问题上取得了实质性的理论成果，目前正在进行验证实验。 该项目将解决在未来两到三年内随着实验进展而出现的许多理论挑战。更广泛的影响：该项目的研究成果将通过组织会议、研讨会和短期课程向社区传播。我们将加倍努力，以确保我们的研究和教育活动的好处达到代表性不足的少数民族（一）使我们的基因组学课程提供给少数民族机构;（二）积极与那里的研究人员合作;（三）招募更多的妇女和少数民族学生到我们的实验室。 我们目前在这些方面的努力将保持在同一水平，如果不是进一步加强的话。我们的工作最重要的长期影响将是用来自工程方法的个性化定制和更好的癌症疗法取代现有的一刀切的癌症疗法。