Anhydrous Fluoride Salts

本项目的重点是发展生产无水氟试剂的环保技术，阐明无水氟化铵盐的基本溶液性质，并示范这些试剂在合成化学中的用途。将合成多种新型无水氟化物盐。将进行以这些新盐为特征的亲核氟化反应的互补计算、动力学和合成研究。该项目将对弱电解质的液相行为的理解和提高这些试剂的稳定性和亲核性的设计标准有重要的推动作用。该项目将为快速和选择性地在后期引入氟提供新的试剂和策略。通过这个奖项，有机和大分子化学项目支持了内布拉斯加大学林肯分校化学系的Stephen G. DiMagno教授和马里兰圣玛丽学院的Andrew S. Koch教授的研究。本研究项目开发了快速高效制备含氟有机化合物的新方法。含氟有机化合物是药物配方、农用化学品、PET显像剂和先进材料的关键成分。选择性氟化方法在制药和农业工业中也受到高度重视，目前销售的产品中约有三分之一含有氟化有机化合物。根据该奖项开发的氟化试剂和方法的直接性质和安全性使本科生研究人员有可能对技术相关研究作出直接和重大的贡献。

This project is focused on the development of environmentally-friendly techniques for generating anhydrous fluoride reagents, the elucidation of fundamental solution properties of anhydrous ammonium fluoride salts, and the demonstration of the utility of these reagents in synthetic chemistry. A diverse collection of new anhydrous fluoride salts will be synthesized. Complementary computational, kinetic and synthetic studies of nucleophilic fluorination reactions featuring these new salts will be performed. This project should advance significantly the understanding of solution phase behavior of weak electrolytes and the design criteria to enhance the stability and nucleophilicity of these reagents. The project will provide new reagents and strategies for the rapid and selective late stage introduction of fluorine. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Stephen G. DiMagno of the Department of Chemistry at the University of Nebraska-Lincoln, and Professor Andrew S. Koch of St. Mary's College of Maryland. This research program develops new methodology to prepare fluorinated organic compounds rapidly and efficiently. Fluorinated organic compounds are critical components of drug formulations, agrochemicals, PET imaging agents, and advanced materials. Selective fluorination methods are also highly prized in the pharmaceutical and agricultural industries, where approximately one third of currently marketed products contain fluorinated organic compounds. The straightforward nature and safety of fluorinating reagents and methods developed under this award make it possible for undergraduate researchers to make direct and significant contributions to technologically relevant research.