Catalytic Minimalism from Nature

来自自然的催化极简主义

• 批准号: 0718625
• 负责人: Li-June Ming
• 金额: $ 27万
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0718625&HistoricalAwards=false
• 关键词: Catalytic; Minimalism; Nature

Professor Li-June Ming, Department of Chemistry, University of South Florida, is supported by the Inorganic, Bioinorganic, and Organometallic Program of the Chemistry Division to develop structure-activity relationships based on the structures, activities and mechanisms of a family of natural minimalistic systems - metallopeptides. Specifically, metal-binding sites of metalloproteins and natural metallopeptides will serve as the blueprints for the pursuit of the structure-activity correlations in oxidation and hydroxylation reactions (catechols and phenol). The results of the proposed research are expected to provide a molecular and mechanistic basis for metal-oxygen chemistry and to further the design of catalysts for green chemical synthesis. Undergraduate and graduate students in this project will gain interdisciplinary training in inorganic chemistry, chemical and biological catalysis, and physical methods (kinetics and thermodynamics via optical spectroscopy and magnetic resonance techniques). Undergraduates are particularly encouraged to become involved in research early in their careers as this better prepares them for graduate or other professional programs.

南佛罗里达大学化学系Li-June Ming教授得到化学系无机、生物无机和有机物项目的支持，以天然最小系统-金属肽的结构、活性和机制为基础，发展结构-活性关系。 具体而言，金属蛋白和天然金属肽的金属结合位点将作为追求氧化和羟基化反应（儿茶酚和苯酚）的结构-活性相关性的蓝图。 研究结果为金属氧化学提供了分子和机理基础，并为绿色化学合成催化剂的设计提供了理论依据。 本项目的本科生和研究生将获得无机化学，化学和生物催化以及物理方法（通过光谱和磁共振技术的动力学和热力学）的跨学科培训。 特别鼓励本科生在职业生涯早期参与研究，因为这可以更好地为研究生或其他专业课程做准备。