Discovery Corps Fellowship: S-layer Protein Assembly as a Case Study for the Science Chronicles; an Online View of the Scientific Process

探索军团奖学金：S 层蛋白质组装作为科学编年史的案例研究；

• 批准号: 0725167
• 负责人: Aaron Strickland
• 金额: --
• 依托单位: Cornell Univ - State: AWDS MADE PRIOR MAY 2010
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0725167&HistoricalAwards=false
• 关键词: Discovery; Corps; Fellowship; layer; Protein

Aaron Strickland of Cornell University is a Discovery Corps Postdoctoral Fellow for the 2007-2008 and 2008-2009 academic years. The research is targeted at understanding how bacterial surface-layer (S-layer) proteins self-assemble into two-dimensional, nanoscale arrays. Strickland will exploit this natural process by patterning saccharide monolayers on gold in order to direct S-layer reassembly. The kinetics of the binding between the proteins and the saccharides will be studied using surface plasmon resonance spectroscopy, and the three-dimensional image of the S-layer protein structures will be determined by atomic force microscopy. This research project will be used as a case study for presenting the complexity of the scientific process to the general public. In collaboration with the "Concord Consortium," Dr. Strickland will create open-source software, based on the "Molecular Workbench," which will simulate the molecular events relevant to the S-layer protein research project. This software will be tied into a web-based podcast hosted by collaborators at "Earth & Sky," which also will feature a series of video interviews that chronicle the evolution of the research from the formation of hypotheses, to the evaluation of experiments, to the dissemination of the conclusions. This podcast will be distributed as a pilot for the Chronicles of a Science Experiment, a web-based outlet that will enable the public to follow the progress of scientific research. This Discovery Corps Senior Fellowship is supported by the Division of Chemistry and the Informal Science Education (ISE) program of the Division of Research on Learning in Formal and Informal Settings (EHR/DRL). The Discovery Corps Fellowship Program seeks new postdoctoral and professional development models that combine research expertise with professional service. Discovery Corps Fellows leverage their research expertise through projects that address areas of national need. Their projects enhance research capacity and infrastructure and contribute to workforce development and job creation. The Discovery Corps Program supports both Postdoctoral Fellows and Senior Fellows.

康奈尔大学的 Aaron Strickland 是 Discovery Corps 2007-2008 和 2008-2009 学年的博士后研究员。 该研究旨在了解细菌表面层（S 层）蛋白质如何自组装成二维纳米级阵列。 Strickland 将利用这一自然过程，在金上形成糖单层图案，以指导 S 层重新组装。 将使用表面等离子体共振光谱研究蛋白质和糖之间的结合动力学，并通过原子力显微镜确定S层蛋白质结构的三维图像。 该研究项目将用作案例研究，向公众展示科学过程的复杂性。 Strickland 博士将与“Concord Consortium”合作，创建基于“分子工作台”的开源软件，该软件将模拟与 S 层蛋白质研究项目相关的分子事件。 该软件将与“地球与天空”合作者主持的基于网络的播客捆绑在一起，该播客还将提供一系列视频采访，记录研究从假设的形成到实验评估再到结论传播的演变过程。 该播客将作为科学实验编年史的试点进行分发，这是一个基于网络的媒体，使公众能够跟踪科学研究的进展。 该发现军团高级奖学金由化学部和正式和非正式环境学习研究部 (EHR/DRL) 的非正式科学教育 (ISE) 项目支持。探索军团奖学金计划寻求新的博士后和专业发展模式，将研究专业知识与专业服务相结合。探索军团研究员通过解决国家需求领域的项目利用他们的研究专业知识。他们的项目增强了研究能力和基础设施，并有助于劳动力发展和创造就业机会。发现军团计划支持博士后研究员和高级研究员。