SBIR Phase I: Separation of Uncharged Polymers by Non-Uniform Electroosmotic flow

SBIR 第一阶段：通过非均匀电渗流分离不带电聚合物

• 批准号: 0740267
• 负责人: Mihai Buretea
• 金额: --
• 依托单位: Labrador Research LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0740267&HistoricalAwards=false
• 关键词: SBIR; Phase; Separation; Uncharged; Polymers

This Small Business Innovation Research (SBIR) Phase I will demonstrate electrokinetic separation of uncharged polymers by length. This technique will create specially-designed microfluidic channels using standard microfabrication technology, coupled with electrophoresis equipment and a fluorescence microscope. The separation of uncharged, fluorescent poly(ethylene glycol) polymers at single-monomer resolution will enable the technology to progress to a prototype platform for use in academic, industrial, medical, and environmental laboratories. The broader impacts (commercial potential) of this technology are the ability to separate a chemical mixture into constituents, this is absolutely necessary for all of analytical chemistry. Improvements in speed, quality, efficiency, or resolution of separation techniques will enhance the behind-the-scenes laboratory work that ensures the quality of everyday products. Measuring the level of organic compounds or mineral content in water is often handled by lab technicians operating chromatography tools; the process is expensive and time-consuming. Nevertheless, the application of chromatography in these fields is pervasive. The overall impact from this project would be a faster and less expensive process to separate chemical mixtures.

这个小企业创新研究（SBIR）第一阶段将证明电动分离不带电的聚合物的长度。这项技术将使用标准的微加工技术，结合电泳设备和荧光显微镜，创建专门设计的微流体通道。在单单体分辨率下分离不带电的荧光聚乙二醇聚合物将使该技术发展成为用于学术，工业，医疗和环境实验室的原型平台。这项技术的更广泛的影响（商业潜力）是将化学混合物分离成组分的能力，这对所有分析化学都是绝对必要的。分离技术在速度、质量、效率或分辨率方面的改进将加强幕后实验室工作，以确保日常产品的质量。测量水中有机化合物或矿物质含量的水平通常由操作色谱工具的实验室技术人员处理;该过程昂贵且耗时。然而，色谱法在这些领域的应用是普遍的。该项目的总体影响将是一个更快、更便宜的分离化学混合物的过程。