权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

STTR Phase I: Smart SAM for Visible Detection of Paralytic Shellfish Toxins

STTR 第一阶段：用于可见检测麻痹性贝类毒素的智能 SAM

基本信息

批准号：
0740590
负责人：
Penny Lewis
金额：
--
依托单位：
White River Bioscience, Inc.
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2008
资助国家：
美国
起止时间：
2008-01-01 至 2009-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0740590&HistoricalAwards=false
关键词：
STTR Phase Smart SAM Visible

项目摘要

This Small Business Technology Transfer Phase I project applies newly developed technology to construct a "smart" Self-Assembled Monolayer (SAM) for the rapid detection of Paralytic Shellfish Toxins, (PSTs), which are neurotoxic seafood poisons produced by algae then accumulated in filter-feeding shellfish. The disease that results from ingestion of contaminated shellfish is called Paralytic Shellfish Poisoning or PSP. The proposed technology could be applicable to an inexpensive, portable device, to an accessory for a benchtop fluorometer, or in an array for high throughput analysis. The broader impacts of this research are related to the protection of human health by providing an alternative to animal testing in determining the safety of shellfish for human consumption. PSTs can be fatal to humans. PST detection programs may use a number of techniques, but mouse bioassay is the current benchmark technique in the food safety arena. This method involves injection of a shellfish extract into a mouse. The time it takes the mouse to die correlates with toxicity. The mouse bioassay is a reliable indicator of human toxicity, but it is expensive and time consuming, especially for large numbers of samples. For both economic and ethical reasons, an alternative is highly desirable.

这个小型企业技术转让第一阶段项目应用新开发的技术来构建一个“智能”自组装单分子层（SAM），用于快速检测麻痹性贝类毒素（PST），这是一种由藻类产生的神经毒性海鲜毒素，然后在滤食性贝类中积累。这种疾病是由于食用了受污染的贝类而引起的，称为麻痹性贝类中毒或PSP。所提出的技术可以适用于廉价的便携式设备，台式荧光计的附件，或用于高通量分析的阵列。这项研究的更广泛影响与保护人类健康有关，为确定人类食用贝类的安全性提供了动物试验的替代方案。PSTs可能对人类致命。PST检测程序可能使用许多技术，但小鼠生物测定是目前食品安全竞技场中的基准技术。该方法包括将贝类提取物注射到小鼠体内。小鼠死亡所需的时间与毒性相关。小鼠生物测定是人类毒性的可靠指标，但它昂贵且耗时，特别是对于大量样品。出于经济和道德的原因，替代品是非常可取的。