CAREER: Synthetic Co-Hosts for Sequence-Specific Recognition and Labeling of Peptides in Aqueous Solution

职业：用于水溶液中肽的序列特异性识别和标记的合成共宿主

• 批准号: 0748483
• 负责人: Adam Urbach
• 金额: $ 56.45万
• 依托单位: Trinity University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748483&HistoricalAwards=false
• 关键词: CAREER; Synthetic; Co; Hosts; Sequence

Professor Adam Urbach, of the Department of Chemistry at Trinity University, is supported by the Organic and Macromolecular Chemistry Program for his research involving the design of molecules that recognize and label specific peptides in aqueous solution. Such compounds would have broad impact on fields ranging from basic biochemistry to medical diagnostics and therapeutics. Current approaches are synthetically challenging and thus inefficient. The PI plans to develop an approach to modifying synthetic peptide receptors that will enable rapid iteration of their design, synthesis, and characterization, thus substantially accelerating the discovery process. The teaching portion of the project focuses on incorporating undergraduate and postdoctoral students in the research, and on improving the integration of teaching and research at Trinity, with a focus on writing and experimental design skills.

来自三一大学化学系的Adam Urbach教授，因其在水溶液中识别和标记特定肽的分子设计方面的研究，获得了有机和大分子化学项目的支持。这些化合物将对从基础生物化学到医学诊断和治疗等领域产生广泛影响。目前的方法具有综合挑战性，因此效率低下。PI计划开发一种方法来修饰合成肽受体，使其设计、合成和表征能够快速迭代，从而大大加快发现过程。该项目的教学部分侧重于将本科生和博士后学生纳入研究，并提高三一学院的教学与研究的整合，重点是写作和实验设计技能。