CAREER:The Physics of Signaling in Cell Membranes: Phosphoinositides and Small GTPases as a Paradigm.

技术概述：该职业奖支持细胞膜中信号分子物理学的教育、理论和计算研究。该研究涉及多个尺度的理论和计算建模。基本的基础描述了脂-蛋白质和蛋白质-蛋白质的相互作用，最终的观点是理解这些如何进入整个细胞水平上细胞功能的决定。拟议的工作将包括原子水平分辨率的多肽-磷脂相互作用的研究。这一水平的理解为通过粗粒度模型描述磷脂-蛋白质和蛋白质-蛋白质相互作用提供了输入。在最高级的阶段，这项工作将扩展这些粗粒度的蛋白质和脂肪模型，以研究流体动力学相互作用。该奖项支持相关的教育活动，通过将本科生和研究生融入研究过程来促进教学、培训和学习。这项研究将通过研讨会和其他正式和非正式的互动，为支持爱荷华州K-12社区教育的外联活动提供信息。其中包括与当地高中合作，用计算方法加强科学教育，让学生有能力建立自然过程的计算机模型。通过让研究生和本科生参与研究，这项工作还将提供基于尖端科学的计算机建模能力的教育，从而提高学生的教育和专业技能。非技术总结：这个职业奖项支持教育，以及活细胞与环境相互作用的机制的分子物理学的理论和计算研究。这项研究的目的是通过细胞膜中发生的复杂过程来了解材料和信息的进出细胞的运输。这项研究涉及多个尺度的理论和计算建模，对构成膜的单个分子和执行信号传递的蛋白质进行研究，然后建立对信号和运输过程如何在整个细胞水平上与细胞功能起作用的更一般的理解。该奖项支持相关的教育活动，通过将本科生和研究生融入研究过程来促进教学、培训和学习。这项研究将通过研讨会和其他正式和非正式的互动，为支持爱荷华州K-12社区教育的外联活动提供信息。其中包括与当地高中合作，用计算方法加强科学教育，让学生有能力建立自然过程的计算机模型。通过让研究生和本科生参与研究，这项工作还将提供基于尖端科学的计算机建模能力的教育，从而提高学生的教育和专业技能。

TECHNICAL SUMMARY:This CAREER award supports education, and theoretical and computational research on the molecular physics of signaling in cell membranes. The research involves theoretical and computational modeling at multiple scales. The fundamental underpinnings describe lipid-protein and protein-protein interactions with an ultimate view of understanding how these enter into the determinations of cell functions at the whole cell level. The proposed work will consist of investigation of peptide-phospholipid interactions with atomic level resolution. The understanding at this level provides input for the description of phospholipids-protein and protein-protein interactions by coarse-grained models. In the most advanced stages, this work then takes up extending these coarse-grained models of proteins and lipids to investigate hydrodynamic interactions. The award supports related educational activities that promote teaching, training and learning via integration of undergraduate and graduate students into the research process. The research will inform outreach activities supporting education in Iowa K-12 communities through workshops and other formal and informal interactions. Among these will be the involvement with local high schools to enhance science education with computational methods giving students capabilities of computer models of natural processes. By engaging graduate and undergraduate students in research, students at the university level, this work will also be providing education in cutting edge scientific based computer modeling capabilities and so enhance student education and professional skills.NON-TECHNICAL SUMMARY:This CAREER award supports education, and theoretical and computational research on the molecular physics of the mechanisms employed by living cells to interact with the environment. The research is motivated to understand transport of materials and information, into and out of a cell, through complex processes occurring in the cell membrane. The research involves theoretical and computational modeling at multiple scales, taking studies of individual molecule that form the membranes and the proteins that carry out the signaling and then building up to more general understanding of how signaling and transport processes work with cell functions at the whole cell level. The award supports related educational activities that promote teaching, training and learning via integration of undergraduate and graduate students into the research process. The research will inform outreach activities supporting education in Iowa K-12 communities through workshops and other formal and informal interactions. Among these will be the involvement with local high schools to enhance science education with computational methods giving students capabilities of computer models of natural processes. By engaging graduate and undergraduate students in research, students at the university level, this work will also be providing education in cutting edge scientific based computer modeling capabilities and so enhance student education and professional skills.