High-Resolution Integrated Ultrasound and Microwave Imaging for Early-Stage Breast Cancer Diagnosis

CBET-0756338，莫哈丹PI建议结合两种非电离成像方式，超声波和微波，以利用由此产生的协同成像特性。超声组件将提供有关不明组织肿块的形状和位置的信息。该微波组件利用非线性时间域逆散射技术，并将提供关于组织的介电常数和电导率的定量信息。与目前需要验证的系统不同，建议的成像系统可以提供组织肿块/病变的明确诊断，大大降低假阳性和假阴性报告的百分比。当与超声形状功能结合使用时，它可以提供具有更高分辨率、空间保真度以及量化和表征组织类型的能力的成像系统。最初，US和MW测量将在算法开发的早期阶段同时和独立进行。建议的成像系统可能提供低于5毫米的分辨率。

CBET-0756338, MoghaddamThe PI proposes combining two non-ionizing imaging modalities, ultrasound and microwave, to take advantage of the synergistic imaging properties that result. The ultrasound component will provide information regarding shape and location of unidentified tissue masses. The microwave component utilizes nonlinear time domain inverse scattering techniques and would provide quantitative information regarding the dielectric constant and conductivity of the tissue. Unlike the current systems that require verification, the proposed imaging system could provide a definitive diagnosis of the tissue mass /lesion significantly reducing the percent of false positive and false negative reports. When used in combination with the ultrasound shape functions it could provide an imaging system with increased resolution, spatial fidelity, and ability to quantify and characterize the tissue type. Initially the US and MW measurements will be taken simultaneously and independently during the early stages of algorithm development. The proposed imaging system could possibly provide a resolution of less than 5mm.