INTERNATIONAL - Isotopic Perturbation of Methyl Rotation in Carbocations

这项资助下最重要的研究课题可能是将核磁共振同位素摄动方法（起源于桑德斯实验室，并已应用于涉及碳正离子结构和重排的许多问题）扩展到甲基的旋转被同位素干扰的情况。这一创新将在碳正离子领域之外有许多重要的应用。预计该方法将用于在小于三重对称的环境中探测甲基的非等效CH键的细微差异。更广泛的影响是通过期望有来自克罗地亚和耶鲁大学的学生（包括女性）参与来解决的。预期参加这项赠款所支持的工作将对他们的教育有很大的帮助。

Probably the most important topic to be investigated under this grant is the proposed new extension of the NMR isotopic perturbation method (which originated in the Saunders Laboratory and has been applied to many problems involving carbocation structures and rearrangements) to cases where the rotation of a methyl group is isotopically perturbed. This innovation will have a number of important applications outside of the field of carbocations. It is expected that this method will be used to probe subtle differences on the non-equivalent CH bonds to methyl groups in environments of less than three-fold symmetry. The broader impacts are addressed by the expectation of having student involvement (including women) from Croatia and from Yale. It is expected that participation in the work supported by this grant would be a substantial aid to their education.