MRI: Acquisition of Tri-Institutional, Cyber-Enabled Chemistry MALDI-TOF Mass Spectrometer

MRI：收购三机构、网络支持的化学 MALDI-TOF 质谱仪

• 批准号: 0820996
• 负责人: Ivan Dmochowski
• 金额: $ 43.53万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0820996&HistoricalAwards=false
• 关键词: MRI; Acquisition; Tri; Institutional; Cyber

With this award from the Major Research Instrumentation program (MRI), Ivan J. Dmochowski from the University of Pennsylvania will acquire a matrix-assisted laser desorption ionization, time-of-flight (MALDI-TOF) mass spectrometer that will be shared in a cyber-enabled configuration with researchers at two neighboring universities in West Philadelphia, Drexel University and University of the Sciences in Philadelphia. The instrumentation will be used for research involving biological and synthetic molecules of mid-high molecular weights. Specific examples are studies of oligo-anthracycline complexing, chemoselective ligations and controlled oligomerization reactions, development of chemical tools for studying complex biological systems for study of organic synthesis of biomacromolecules, as well as bacterial protein expression. Undergraduate and graduate students from chemistry and biochemistry majors at the three participating institutions will be able to conduct academic-year and summer research.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights of very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially chemistry and biochemistry.

凭借重大研究仪器计划 (MRI) 的这一奖项，宾夕法尼亚大学的 Ivan J. Dmochowski 将获得一台基质辅助激光解吸电离飞行时间 (MALDI-TOF) 质谱仪，该质谱仪将通过网络配置与西费城两所相邻大学（德雷塞尔大学和科学大学）的研究人员共享。 费城。 该仪器将用于涉及中高分子量生物和合成分子的研究。具体例子包括寡蒽环类药物络合、化学选择性连接和受控寡聚反应的研究、用于研究复杂生物系统的化学工具的开发、用于研究生物大分子的有机合成以及细菌蛋白质表达。 三个参与机构的化学和生物化学专业的本科生和研究生将能够进行学年和暑期研究。MALDI-TOF 质谱是获得非常大分子的准确分子量的首选技术，具有极高的灵敏度。因此，MALDI-TOF 质谱仪的使用已成为一种标准技术，特别是在涉及生物分子的研究中。这项研究将在许多领域产生重大影响，特别是化学和生物化学。