Collaborative Research: Scaling Laws for NanoFET Biosensors

合作研究：纳米场效应晶体管生物传感器的尺度规律本研究的目的是发展对纳米场效应晶体管生物传感器的性能在不同物理条件下如何取决于器件几何尺寸的基本认识。该方法采用随机电阻网络模型对不同物理条件下器件的标度行为进行数值研究，并以硅基器件为模型系统对不同场效应强度下的标度规律进行实验测试。智力价值：这项研究的结果将回答一个根本性的有趣的和技术上重要的问题，即场效应生物传感器的灵敏度和检测极限是否以及如何取决于它们的几何尺寸和相关的物理参数。该项目具有变革性，因为将场效应生物传感器的缩放定律作为关键设计指南，将能够根据目标分析物浓度定制灵敏度和检测限，并能够设计超低检测限的设备。更广泛的影响：超灵敏的生物传感器可以找到各种应用，从食品安全，国土安全到人类健康保健的疾病诊断。研究生和本科生将在这个跨学科项目中接受器件和计算物理、半导体纳米结构制造和表征、表面和界面生物化学的培训。将作出特别努力，招收女性和代表性不足的少数民族学生参加。这个项目的研究发现将被纳入主要研究者开发的课程中。拓展活动包括参观学校、培训高中高年级学生、参与NSF GK-12项目。

Collaborative Research: Scaling Laws for NanoFET BiosensorsThe objective of this research is to develop fundamental understanding on how the performance of nanoscale field effect transistor biosensors depends on device geometrical sizes at different physical conditions. The approach is to numerically investigate device scaling behaviors at various physical conditions by using a random resistor network model and experimentally test these scaling laws at different field effect strengths by using Si-based devices as a model system.Intellectual Merit: The outcome of this research will answer the fundamentally intriguing and technologically important question on whether and how the sensitivity and detection limits of field effect biosensors depend on their geometrical dimensions and relevant physical parameters. The project is transformative in terms that scaling laws for field effect biosensors as critical design guidelines will enable tailoring the sensitivity and detection limits in accordance with target analyte concentrations, and enable design of devices with ultra-low detection limits. Broader Impacts: Ultra-sensitive biosensors can find various applications from food safety, homeland security to disease diagnostics for human health care. Graduate and undergraduate students will be trained in this interdisciplinary project on device and computational physics, semiconductor nanostructure fabrication and characterization, and surface and interface biochemistry. Special efforts will be made to recruit female and underrepresented minority students for participation. Research discoveries from this project will be incorporated into the courses developed by the principle investigators. Outreach activities include school visits, training of high school senior students, and participation of NSF GK-12 Program.