Mechanisms and consequences of myeloperoxidase-mediated damage to glycosaminoglycans, proteins and proteoglycans

动脉粥样硬化（动脉硬化）是导致包括澳大利亚在内的发达国家和发展中国家40%人口死亡的原因。动脉粥样硬化病变纤维帽破裂是大多数心脏病和中风猝死的原因，但对这一过程了解甚少。已经有证据表明氧化反应在削弱病变结构和使其易于破裂方面的作用。人们对这种损伤的基本化学原理知之甚少；这将在拟议的计划中得到解决。获得的数据将支持制定新的预防和保护战略，以尽量减少这种主要疾病造成的病变破裂和死亡。

Atherosclerosis (hardening of the arteries) is responsible for the death of 40% of the population of developed, and developing, countries including Australia. Rupture of the fibrous cap of atherosclerotic lesions is responsible for most sudden deaths from heart disease and stokes, but is a poorly understood process. Evidence has been presented for a role for oxidation reactions in weakening the structure of lesions and making them prone to rupture. Little is known about the fundamental chemistry of such damage; this will be addressed in the proposed program. The data obtained will underpin the development of new preventative and protective strategies to minimise lesion rupture and deaths from this major disease.