CAREER: Unlocking the Synthetic Potential of N-Allylhydrazones

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。该项目将继续为化学合成开发强大的新反应和策略。这项拟议的研究旨在开发非常有用的合成方法，重点是使用N-烯丙基肼作为容易制备的化合物，这些化合物可以进行各种强大的反应。具体地说，这项研究将提供从简单前体制备复杂分子的创造性反应和策略。假说驱动的研究阐明这些新转化的机制将提供对潜在的分子过程的洞察，并为未来的反应发展提供信息。将这些反应应用于生物活性分子的靶向合成，将证明这些方法的实用性和更广泛的影响。通过这一奖项，有机和高分子化学项目支持西北大学化学系教授里根·J·汤姆森的研究。里根·汤姆森教授的研究工作围绕着强大的合成转化的发展，特别是N-烯丙基肼的转化。这样的化学将有助于我们从简单的积木构建复杂的分子结构的基本能力。该方法的成功开发将对制药行业的合成产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will continue work on developing powerful new reactions and strategies for chemical synthesis. The proposed research aims to develop highly useful synthetic methods centered on the use of N-allylhydrazones as readily prepared compounds that can undergo a diverse array of powerful reactions. Specifically, the research will provide inventive reactions and strategies for preparing complex molecules from simple precursors. Hypothesis driven studies to elucidate the mechanism of these new transformations will provide insight into the underlying molecular processes and inform future reaction development. Application of the reactions in the context of target-directed synthesis of bioactive molecules will demonstrate the methods' usefulness and broader impacts. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Regan J. Thomson of the Department of Chemistry at Northwestern University. Professor Regan Thomson's research efforts revolve around the development of powerful synthetic transformations, in particular those of N-allylhydrazones. Such chemistry will contribute to our fundamental ability to construct complicated molecular structures from simple building blocks. Successful development of the methodology will have an impact on synthesis in the pharmaceutical industry.