Identification of Dominant Paths for Biochemical Reaction Networks from Incomplete Data

从不完整数据中识别生化反应网络的主要路径

• 批准号: 0847073
• 负责人: John Ross
• 金额: $ 40.3万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847073&HistoricalAwards=false
• 关键词: Identification; Dominant; Paths; Biochemical; Reaction

John Ross of Stanford University is supported by an award from the Theoretical and Computational Chemistry program within the Division of Chemistry for the development of methods and tools to determine dominant reaction pathways in complex biochemical networks. The approach is based on the use of a generalized Fisher law, combined with a renormalization group approach, and applied to response experiments. Statistical approaches for identifying dominant reaction pathways from incomplete data collected from response experiments have been introduced. These methods permit the analysis of incomplete experimental data in biochemical reactions.The broader impacts of this work involve an international collaboration to apply these methods to study several biological systems: to the study of yeast metabolism and blood coagulation. It is expected that the blood coagulation model will be implemented in clinical software programs for improved prediction of the dosage of oral coagulants.

斯坦福大学的约翰·罗斯（John Ross）获得了化学系理论和计算化学项目的奖励，用于开发确定复杂生化网络中主要反应途径的方法和工具。 该方法基于广义费舍尔定律的使用，结合重整化群方法，并应用于响应实验。从响应实验收集的不完整数据中识别主导反应途径的统计方法已经被引入。这些方法允许分析生化反应中不完整的实验数据。这项工作的更广泛影响涉及国际合作， 应用这些方法来研究几个生物系统：酵母代谢和血液凝固的研究。预计血液凝固模型将在临床软件程序中实现，以改善口服凝血剂剂量的预测。