CAREER: Oxidative Cross-Coupling--An Efficient and Green Method for Synthesizing Biaryls

职业：氧化交叉偶联——一种高效、绿色的联芳基化合物合成方法

• 批准号: 0847222
• 负责人: Brenton DeBoef
• 金额: $ 55万
• 依托单位: University of Rhode Island
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847222&HistoricalAwards=false
• 关键词: CAREER; Oxidative; Cross; Coupling; Efficient

This project will develop new oxidative cross coupling reactions for the synthesis of biaryl molecules and will test a mechanistic hypothesis for this novel process. The primary goal of the work is the development of a model that explains the observed phenomena and can be used to predict the ideal reaction conditions for a given aryl substrate. Systematic competition and kinetic studies will be used to probe the reaction mechanism, and the information gleaned from these experiments will be used to develop new oxidative coupling reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Brenton DeBoef of the Department of Chemistry at the University of Rhode Island. Professor DeBoef's research efforts are focused on the invention of new chemical reactions that cleave strong carbon-hydrogen bonds and form new carbon-carbon bonds in a single step. These new processes may streamline the synthesis of high-value molecules such as drugs, herbicides, and dyes for organic light emitting diodes. Additionally these novel reactions have less environmental impact than many of the existing technologies. Dr. DeBoef is also developing new research-oriented curricula involving multi-step chemical synthesis and green chemistry. Undergraduate and graduate students are being trained for careers as synthetic chemists in the global marketplace, and will benefit from the International Chemistry Program that Dr. DeBoef is developing at the University of Rhode Island.

本计画将发展新的氧化交叉偶合反应来合成联芳基分子，并将测试此新制程的机制假说。 这项工作的主要目标是开发一个模型，解释所观察到的现象，并可用于预测一个给定的芳基底物的理想反应条件。 系统的竞争和动力学研究将用于探索反应机理，从这些实验中收集的信息将用于开发新的氧化偶联反应。 有了这个奖项，有机和高分子化学计划正在支持罗得岛大学化学系的Brenton DeBoef教授的研究。 DeBoef教授的研究工作集中在新的化学反应的发明上，这些化学反应可以在一个步骤中切割强的碳-氢键并形成新的碳-碳键。 这些新工艺可以简化高价值分子的合成，如药物，除草剂和有机发光二极管染料。 此外，这些新反应比许多现有技术对环境的影响更小。 DeBoef博士还在开发新的研究型课程，涉及多步化学合成和绿色化学。 本科生和研究生正在接受培训，以在全球市场上从事合成化学家的职业，并将受益于DeBoef博士在罗得岛大学开发的国际化学计划。