Cyberinfrastructure for Accessible and Reproducible Research in Life Sciences

宾夕法尼亚州立大学园区获得了一笔赠款，用于扩展现有的软件系统Galaxy(http://galaxyproject.org))，该系统集成了计算生物学工具，供实验生物学家访问序列、多态和功能数据集。需要加强的分析功能包括一套工具，使科学家无需离开他们的网络浏览器就可以利用全基因组多重比对执行大规模分析；用于对高通量基因分型实验产生的数据进行全面分析的交互式统计遗传学工具包；用于检测选择、重组和其他关键进化参数的进化分析工具包，它可以直接应用于现有的序列和比对数据集；以及通过实施简单但强大的分析工作流程提高生命科学研究的重复性的新方法。该项目是与布里格姆妇女医院、埃默里大学和加州大学圣迭戈分校的合作努力。Galaxy通过使现有工具的界面现代化变得琐碎，将新工具的开发人员从从头开始开发界面的需要中解放出来，通过无缝集成不同的工具和数据库来促进工具的互操作性和复杂的分析，从而弥合了计算工具和用户之间至关重要的鸿沟。银河有两个蓬勃发展的用户社区：一个是使用公共的银河实例，只需一个Web浏览器就可以访问各种工具和数据库；另一个是利用银河框架？S的可移植性和最低的安装要求来创建自己的银河实例，并提供对本地开发的工具和私有数据的轻松访问。

Pennsylvania State University University Park is awarded a grant to extend an existing software system, Galaxy (http://galaxyproject.org) that integrates computational biology tools for experimental biologists to access sequence, polymorphism and functional datasets. Analytic functions to be enhanced include a set of tools allowing bench scientists to perform large-scale analyses with whole-genome multiple alignments without ever leaving their web browsers; an interactive statistical genetics tool kit for comprehensive analysis of data generated from high-throughput genotyping experiments; an evolutionary analysis toolset for detection of selection, recombination and other critical evolutionary parameters, that can be applied directly to existing sequence and alignment datasets; and novel approaches for improving reproducibility of research in life sciences by implementing simple yet powerful analysis workflows that can be constructed by example and explicitly. The project is a collaborative effort with Brigham and Women's Hospital, Emory University, and University of California, San Diego.Galaxy bridges a critically important gap between computational tools and users, by making it trivial to modernize the interfaces of existing tools, freeing developers of new tools from the need to develop interfaces from scratch, and facilitating tool interoperability and complex analyses by seamlessly integrating diverse tools and databases. Galaxy has two thriving communities of users: those who use the public Galaxy instance to access a variety of tools and databases with nothing more than a web browser, and those who take advantage of Galaxy framework?s portability and minimal installation requirements to create their own Galaxy instances and provide easy access to locally developed tools and private data.