Postdoctoral Research Fellowships in Biology for FY 2009

2009财年生物学博士后研究奖学金

• 批准号: 0905714
• 负责人: Matthew Fujita
• 金额: --
• 依托单位: Fujita Matthew K
• 依托单位国家: 美国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0905714&HistoricalAwards=false
• 关键词: Postdoctoral; Research; Fellowships; Biology; FY

This action funds an NSF Postdoctoral Research Fellowship for FY 2009 using funds from the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The research and training plan is for Matthew K. Fujita and is entitled "Genome structure and its influence on the efficacy of natural selection in reptiles." The host institution for this research is Harvard University under the sponsorship of Dr. Scott Edwards.Variation in the arrangement of the building blocks of DNA define the structure of the genome, and this structure can have a profound influence on the performance of natural selection. There are strong correlations between signatures of natural selection and structural components of genomes in organisms that are traditional models for genetics research, but not much is known about these relationships in organisms that are not traditional models, such as reptiles. This research (1) identifies and describes the structural components of reptile genomes using the recently-sequenced Anolis lizard genome and an upcoming turtle genome and (2) examines how these structural components affect forces such natural selection that influence genome evolution. This research provides a vision of how evolutionary biologists who study natural populations can utilize these increasingly large and complex datasets with important and relevant questions towards understanding the evolutionary processes responsible for the origin of biological diversity. Training plans include developing techniques in genomic data organization, computational methods, and statistical analyses. There is also a strong international component to this research that brings together researchers from Harvard University, the Broad Institute in Cambridge, Mass. USA, and Oxford University in the United Kingdom.

这项行动为2009财政年度的NSF博士后研究奖学金提供资金，该奖学金使用2009年美国复苏和再投资法案（公法111-5）的资金。研究和培训计划是为马修·K。藤田和题为“基因组结构及其对爬行动物自然选择效力的影响。“这项研究的主办机构是由斯科特·爱德华兹博士赞助的哈佛大学。DNA构建块排列的变异定义了基因组的结构，而这种结构可以对自然选择的表现产生深远的影响。在作为遗传学研究传统模型的生物体中，自然选择的特征与基因组的结构成分之间存在很强的相关性，但对于非传统模型的生物体（如爬行动物）中的这些关系知之甚少。这项研究（1）使用最近测序的Anolis蜥蜴基因组和即将到来的海龟基因组识别和描述爬行动物基因组的结构组成部分，（2）研究这些结构组成部分如何影响影响基因组进化的自然选择。这项研究提供了一个愿景，研究自然种群的进化生物学家如何利用这些日益庞大和复杂的数据集，了解负责生物多样性起源的进化过程的重要和相关的问题。培训计划包括开发基因组数据组织，计算方法和统计分析方面的技术。这项研究也有很强的国际性，汇集了来自哈佛大学、马萨诸塞州剑桥的布罗德研究所的研究人员。美国和英国牛津大学。