Minority Postdoctoral Research Fellowships in Biology for FY 2009

2009 财年生物学少数族裔博士后研究奖学金

• 批准号: 0905813
• 负责人: Zomary Flores
• 金额: $ 18.9万
• 依托单位: Flores Zomary
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0905813&HistoricalAwards=false
• 关键词: Minority; Postdoctoral; Research; Fellowships; Biology

This action funds an NSF Minority Postdoctoral Research Fellowship for FY 2009 and is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The fellowship supports a research and training plan in a host laboratory for the Fellow who also presents a plan to broaden participation in biology. The title of the research and training plan for this fellowship to Zomary Flores is "Role of methionine sulfoxide reductases in the oxidative stress response of Vibrio fischeri and Euprymna scolopes light organ colonization." The host institution for this research is the University of Georgia under the sponsorship of Dr. Eric Stabb.Humans, animals, and plants interact with microbes throughout their life. Some of these interactions may be beneficial or harmful to the host's health. Host-derived reactive oxygen species (ROS) play important roles in the maintenance of beneficial and pathogenic microbial infections as they can cause protein, membrane, and DNA damage in the microbe. The bioluminescent bacterium Vibrio fischeri forms a natural symbiosis with the bobtail squid (Euprymna scolopes). This interaction is an important model for more complex and less well-defined beneficial animal-microbe interactions. This research focuses on a protein repair system from V. fischeri, called methionine sulfoxide reductase (Msr). Specifically, the results clarify the roles of Msr in the bacterium's ROS resistance, bioluminescence, and host interaction. In addition, proteins targeted by this repair system in V. fischeri are being identified.Training objectives of this research include developing and expanding laboratory technical skills. Host-microbe interactions play important roles in host health, so further understanding of the mechanisms that are involved in maintenance of these beneficial infections is critical for understanding plant, animal, and human health. This research contributes to understanding host-associated microbe resistance to host-defenses and provides insight into the behavior of microbes that form persistent pathogenic infections. Broader impacts also include mentoring undergraduate students from underrepresented groups.

该行动资助了2009财年的NSF少数民族博士后研究奖学金，并根据2009年美国复苏和再投资法案（公法111-5）提供资金。该研究金支持研究员在东道实验室的研究和培训计划，研究员还提出了扩大生物学参与的计划。Zomary弗洛雷斯的研究和培训计划的标题是“蛋氨酸亚砜还原酶在费氏弧菌和Euprymna palopes光器官定植的氧化应激反应中的作用”。“这项研究的主办机构是格鲁吉亚大学，由埃里克·斯塔布博士赞助。人类、动物和植物在其一生中都与微生物相互作用。 其中一些相互作用可能对宿主的健康有益或有害。 宿主来源的活性氧（ROS）在维持有益和致病微生物感染中起重要作用，因为它们可导致微生物中的蛋白质、膜和DNA损伤。 生物发光细菌Vibrio fischeri与短尾鱿鱼（Euprymna sputteropes）形成自然共生关系。 这种相互作用是更复杂和不太明确的有益的动物-微生物相互作用的重要模型。 这项研究的重点是来自费氏弧菌的蛋白质修复系统，称为蛋氨酸亚砜还原酶（Msr）。 具体而言，结果阐明了Msr在细菌的ROS抗性，生物发光和宿主相互作用中的作用。 此外，正在鉴定费氏弧菌中这种修复系统的靶蛋白。这项研究的培训目标包括发展和扩大实验室技术技能。 宿主-微生物相互作用在宿主健康中起着重要作用，因此进一步了解维持这些有益感染的机制对于理解植物，动物和人类健康至关重要。这项研究有助于了解宿主相关微生物对宿主防御的抗性，并提供了对形成持续性病原体感染的微生物行为的深入了解。 更广泛的影响还包括指导来自代表性不足群体的本科生。