SBIR Phase I: High sensitivity nanoplasmonic biosensors

该SBIR第一阶段研究项目将展示一种光流控芯片级生物传感器系统，用于小体积和低成本的无标记，高通量，实时监测和检测多种生化反应的动态。许多应用促使开发新的生物传感器，其提供高灵敏度和分辨率以使得能够检测单个或少量分子，并且通过大量并行测试通道实现高通量以增加测试变化谱并减少假警报。所提出的方法显着提高了生物传感器的灵敏度和分辨率，通过利用新型偏振敏感的激发和检测的表面等离子体激元共振的金属薄膜穿孔的2D纳米孔阵列的优化的金属-电介质复合纳米结构的研究结果。这种生物传感器系统将具有直接的技术和商业影响，因为它提供了独特的性能特征（例如，例如，在一个实施例中，无标记、高通量筛选、高灵敏度）。拟议中的生物传感器系统也将影响在军事，国土安全，农业和环境监测应用中的生化制剂的检测。该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。

This SBIR Phase I research project will demonstrate an opto-fluidic chip-scale bio-sensor system for label-free, high-throughput, real-time monitoring and detection of dynamics of multitude of biochemical reactions in small volumes and at low cost. Numerous applications urge development of new biological sensors that provide high-sensitivity and resolution to enable detection of single or small number of molecules and high-throughput enabled by large numbers of parallel testing channels to increase test variation spectrum and reduce false alarms. The proposed approach significantly enhances the biosensor sensitivity and resolution by utilizing the results of research on novel polarization sensitive excitation and detection of surface plasmon polariton resonance in metal films perforated by 2D nanohole arrays made of optimized metal-dielectric composite nanostructure. This bio-sensor system will have direct technological and commercial impact because it provides unique performance characteristics (e. g., label-free, high throughput screening, high-sensitivity) at low cost. The proposed bio-sensor system will also impact detection of bio-chemical agents in military, homeland security, agriculture, and environment monitoring applications.This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).