SBIR Phase I: Food Antioxidants (AOs) With or Without Estrogenic Activity (EA)

SBIR 第一阶段：具有或不具有雌激素活性 (EA) 的食品抗氧化剂 (AO)

• 批准号: 0912601
• 负责人: Cathy Yang
• 金额: $ 9.99万
• 依托单位: CertiChem, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0912601&HistoricalAwards=false
• 关键词: SBIR; Phase; Food; Antioxidants; AOs

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Small Business Innovation Research Phase I project will confirm that it is feasible to identify food antioxidants (AOs) to make formulations that have no detectable estrogenic activity (EA) or anti-EA (EA-Free) or have well-specified levels of EA (EA-Specified AO formulations). This project is innovative because food AOs have not previously been examined for levels of EA, especially after common-use-stresses of sterilizing or microwaving. CertiChem is uniquely qualified to develop and commercialize EA-free/EA-specified AO formulations because of its exclusive patents and experience in bringing EA-Free products to market.The broader impacts of this research are that CertiChem's data show that most current food AOs have EA in unknown concentrations. CertiChem proposes to develop AO formulations that are EA-Free or have well-specified levels of EA. Chemicals having EA at concentrations used in foodstuffs (mM to uM) often have adverse effects on mammals, including humans. Fetal or juvenile mammals are especially sensitive to effects of chemicals having EA at very low dosages (nM to pM concentrations). Conversely, some conditions in adult humans (e.g., menopause, some cancers or abnormalities of the prostate) are probably ameliorated by chemicals having well-specified levels of EA. CertiChem is raising consumer awareness by actively working with NGOs and legislators to educate the public on health risks or benefits associated with chemicals that have EA. Significant consumer demand for EA-Free products or EA-Specified products is already observed.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。这个小企业创新研究第一阶段项目将确认确定食品抗氧化剂（AO），使配方没有可检测的雌激素活性（EA）或抗EA（EA-免费）或具有明确规定的EA（EA-指定AO配方）。这个项目是创新的，因为食品AO以前没有检查过EA的水平，特别是在常用的消毒或微波压力之后。CertiChem是唯一有资格开发和商业化EA免费/EA指定AO配方，因为它的独家专利和经验，使EA免费产品推向市场。这项研究的更广泛的影响是，CertiChem的数据显示，目前大多数食品AO具有EA在未知的浓度。CertiChem建议开发不含EA或具有明确规定的EA水平的AO制剂。在食品中使用的浓度（mM至uM）下具有EA的化学品通常对哺乳动物（包括人类）具有不利影响。胎儿或幼年哺乳动物对具有极低剂量（nM至pM浓度）的EA的化学品的作用特别敏感。相反，成年人的某些情况（例如，绝经期、某些前列腺癌症或异常）可能通过具有明确的EA水平的化学物质来改善。CertiChem通过积极与非政府组织和立法者合作，教育公众与具有EA的化学品相关的健康风险或益处，提高消费者的意识。消费者对无EA产品或EA指定产品的需求已经很大。