International Collaboration in Chemistry: Transition Metal-Mediated C-C Bond and C-Heteroatom Bond Formations via C-H Activation in Organic Synthesis

本项目将探索通过铂催化的C-H活化反应形成C-C和C-N键的新方法。尽管已知铂络合物介导C-H活化以形成烷基铂或芳基铂物质，但很少有研究针对由这些中间体形成C-C或C-N键。开发新的铂介导的C-H键直接官能化形成C-C和C-N键的方法。阐明了反应机理，为复杂分子的合成提供了新的方法。这些新反应在天然产物合成中的应用将由何教授的中国合作者兰州大学涂永强教授进行。屠教授的工作是由中国国家科学基金（NSFC）单独资助。这个国际化学合作奖，由有机和高分子化学计划和国际科学与工程办公室资助，将支持芝加哥大学化学系的何川教授的工作。何教授的研究工作围绕着开发用于形成C-C和C-N键的简易C-H活化方法。 这种化学将有助于各种化学和药物制剂的能量有效和环境友好的合成。

This project will explore the development of new methods for the formation of C-C and C-N bonds via platinum-catalyzed C-H activation reactions. Although platinum complexes are known to mediate C-H activation to form alkyl-platinum or aryl-platinum species, few studies have been directed toward formation of C-C or C-N bonds from these intermediates. Development of new platinum-mediated methods for formation of C-C and C-N bonds from direct functionalization of C-H bonds will be undertaken. The reaction mechanism will be elucidated and the new methods will be employed in the synthesis of complex molecules. Applications of these new reactions in the synthesis of natural products will be performed by Professor He's Chinese collaborator, Professor Yong-Qiang Tu, of Lanzhou University. Professor Tu's work is separatately supported by the National Science Foundation of China (NSFC). This International Collaborations in Chemistry award, funded by the Organic and Macromolecular Chemistry Program and the Office of International Science and Engineering, will support the work of Professor Chuan He, of the Department of Chemistry at the University of Chicago. Professor He's research efforts revolve around the development of facile C-H activation methods for the formation of C-C and C-N bonds. Such chemistry will contribute to energy efficient and environmentally benign synthesis of various chemical and pharmaceutical agents.