STTR Phase I: Multifunctional Magnetic Core-Shell Nanoparticles

STTR第一期：多功能磁性核壳纳米粒子

• 批准号: 0930634
• 负责人: Jin Luo
• 金额: $ 15万
• 依托单位: NSC Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0930634&HistoricalAwards=false
• 关键词: STTR; Phase; Multifunctional; Magnetic; Core

This Small Business Technology Transfer Phase I project is for the manufacture of multifunctional magnetic core-shell nanoparticles to demonstrate the feasibility of synthesizing core-shell nanoparticles consisting of magnetic nanoparticle cores and gold and/or silver shells. Such nanocomposite materials will be engineered to display controllable surface reactivity (and biocompatibility) from the gold or silver shells, and magnetic separation capability from the magnetic cores. The broad impact of the proposed approach is three-fold in the development of multifunctional nanomaterials. First, the nanoengineering of the metals enables a drastic increase of the surface area and other changes in properties for better bio-probing and antibacterial activity. Secondly, the nanoscale gold/silver shells lead to reduction of the production costs, toxicity and better antimicrobial characteristics. Thirdly, the introduction of magnetic cores enables the capabilities of effective and controlled separation, delivery and targeting of the bio-probes and antibacterial agents. Such products target not only the same commercialization market as magnetic beads in magnetic separation but also many new areas of biotechnologies.This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).

该小企业技术转让第一阶段项目旨在制造多功能磁性核壳纳米颗粒，以证明合成由磁性纳米颗粒核和金和/或银壳组成的核壳纳米颗粒的可行性。 这样的纳米复合材料将被设计成显示来自金或银壳的可控表面反应性（和生物相容性），以及来自磁芯的磁分离能力。所提议的方法在多功能纳米材料的开发方面具有三重广泛影响。首先，金属的纳米工程能够大幅增加表面积和其他性能变化，以获得更好的生物探测和抗菌活性。其次，纳米级金/银壳导致生产成本降低、毒性和更好的抗菌特性。第三，磁芯的引入使得能够有效和受控地分离、递送和靶向生物探针和抗菌剂。这类产品的目标不仅是与磁性分离中的磁珠相同的商业化市场，还包括许多新的生物技术领域。该奖项由2009年美国复苏和再投资法案（公法111-5）资助。