SBIR Phase I: Electrical Property Detection of Residual Cancer in the Surgery Suite

这个小型企业创新研究(SBIR)第一阶段项目在癌症的外科治疗方面提供了实质性的改进。无法通过视觉或触觉找到恶性组织限制了外科医生可以识别和移除的组织。目前，切除受影响的组织必须在病理实验室确认，结果有时会推迟24-36小时。一些患者可能需要接受多次手术才能完全切除癌组织。NovaScan开发了一种高度创新、快速和准确的标准，用于使用组织的组织电特性来检测癌症组织。这项技术将被整合到外科医生使用的手持式探头中，以确定手术伤口和区域淋巴结是否没有癌症。这项研究的更广泛影响与减少重复手术的数量有关，这些手术增加了患者的风险，并在我们努力降低医疗保健成本的同时增加了社会的成本负担。对于乳腺癌，一个组织报告说，48.5%的患者需要进行一次以上的手术来切除已知的癌症。与其他正在研究的方法相比，建议的技术需要更少的时间，不需要样品准备，并且不使用危险试剂进行肿瘤检测。基于早期的研究，NovaScan设备为外科套件或病理实验室提供了一种工具，可以准确地检测肿瘤细胞，而且成本低于目前可用的。

This Small Business Innovation Research (SBIR) Phase I project offers a substantial improvement in the surgical treatment of cancer. The inability to find malignant tissue by sight or touch limits the tissue that the surgeon can identify and remove. Currently, removal of affected tissue must be confirmed in the pathology laboratory resulting in delays of results for sometimes 24-36 hours. Some patients may be subjected to multiple surgeries for the complete removal of the cancerous tissue. NovaScan has developed a highly innovative, rapid and accurate criterion for detecting cancerous tissue using the tissue electrical properties of the tissues. This technology will be incorporated into a hand-held probe used by the surgeon to ascertain that the surgical wound and regional lymph nodes are clear of cancer.The broader impacts of this research are related to reducing the number of repeat surgeries that increase the risk for the patient, and add a cost burden to our society at a time when we are trying to reduce health care costs. For breast cancer, one group has reported 48.5% of patients required more than one operation to removal the known cancer. In contrast to other methods under study, the proposed technology requires less time, no sample preparation, and does not employ the use of hazardous agents for tumor detection. Based on earlier studies, the NovaScan device offers a tool for the surgical suite or pathology laboratory that can detect tumor cells accurately and at lower costs than is currently available.