SBIR Phase I: Novel Ceria Nano-particle Containing Bioactive Scaffolds for Enhanced Bone Regeneration

SBIR 第一阶段：新型含二氧化铈纳米颗粒的生物活性支架，可增强骨再生

• 批准号: 0945068
• 负责人: DAVID GAISSER
• 金额: $ 14.55万
• 依托单位: NOVABONE PRODUCTS, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0945068&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Ceria; Nano

This Small Business Innovation Research (SBIR) Phase I project aims to develop ceria nano-particle coatings on bioactive glass for bone regeneration. The approach is to combine the two different classes of inorganic bioactive materials to obtain a new generation of synthetic bone regenerative materials. This new material will have the capacity, through engineered nanoparticles and tailored kinetic release of specific ions, to stimulate early angiogenesis and provide an ideal scaffold for cell recruitment and proliferation, thereby accelerate the repair process.The broader/commercial impact of this project will be the potential to address the growing need for better solutions of bone regeneration, given the fact that over 10 million Americans have osteoporosis. By developing inorganic materials with specific ionic release and strong anti-oxidative properties, this project is expected to address the demand for adequate bone graft materials to be used throughout the body and achieve the bone regeneration.

这个小型企业创新研究(SBIR)第一阶段项目旨在开发生物活性玻璃上用于骨再生的CeO2纳米颗粒涂层。方法是将这两类不同的无机生物活性材料结合起来，获得新一代合成骨再生材料。这种新材料将通过设计的纳米颗粒和特定离子的量身定做的动力学释放，刺激早期血管生成，并为细胞招募和增殖提供理想的支架，从而加快修复过程。鉴于超过1000万美国人患有骨质疏松症，该项目的更广泛/商业影响将是解决日益增长的对骨再生解决方案的需求。通过开发具有特定离子释放和强大抗氧化性能的无机材料，该项目有望满足人体对足够的骨移植材料的需求，实现骨再生。