Dendrimer-Like Polysaccharides: Structure, Modification, and Functional Colloidal Assembly

树枝状多糖：结构、修饰和功能性胶体组装

• 批准号: 1006301
• 负责人: Yuan Yao
• 金额: $ 35万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1006301&HistoricalAwards=false
• 关键词: Dendrimer; Like; Polysaccharides; Structure; Modification

This award by the Biomaterials program in the Division of Materials Research to Purdue University is to study structure-function relationship of phytoglycogen (PG) nanoparticles and identify key factors for engineering PG nanoparticle-mediated colloidal systems. Biobased nanomaterials have enormous potential in the areas of food safety and nutrition, drug delivery, personal care, and agricultural engineering. In this project, a new class of biobased dendrimer-like polysaccharide nanomaterials will be prepared from PG, which has a particle size of 30-100 nm and an exceptionally high molecular density. After being grafted with amphiphilic groups, PG can be used to form functional colloidal assemblies. An outstanding property of these assemblies is to protect and deliver lipophilic compounds, such as omega-3 fatty acids. The aim of this project is to reveal the native PG that will be extracted from the su1 mutant maize, fractionated, and subjected to chemical and enzymatic modifications. The properties of functionalized PG nanoparticles will be evaluated for their capability to realize enhanced oxidative stability and controlled release of lipids. Supported by this project, a teaching module 'Frontiers in Carbohydrate Design' will be developed and incorporated into the PIs' educational activities. This effort will greatly benefit the undergraduate and graduate students involved, as well as the industrial personnel attending the annual Carbohydrate Short Course at Purdue University.In this project, a carbohydrate polymer, phytoglycogen (PG), is extracted from a corn mutant and transformed into functional nanoparticles. PG is a dendrimer-like polysaccharide made from densely distributed branches. Phytoglycogen-based nanoparticles are digestible and biodegradable, which allows them to deliver bioactive compounds in physiological conditions. For example, these nanoparticles may protect lipid nutrients (e.g. omega-3 fatty acids) from oxidation and release them during digestion. At the fundamental level, this project will establish a new strategy for generating sustainable, environmentally benign, and economical nano-constructs that will benefit the areas of food safety and nutrition, drug delivery, personal care, and agricultural engineering. Supported by this project, a teaching module will be developed to introduce the cutting-edge development of carbohydrate science, including carbohydrate modifications, carbohydrates in food safety and nutrition, carbohydrate-based delivery systems, and carbohydrates and green chemistry. This module will be incorporated into educational activities in the campus for training undergraduate and graduate students, as well as the industrial personnel attending the annual 'Carbohydrate Short Course' at Purdue University.

该奖项由普渡大学材料研究部的生物材料计划授予，旨在研究植物糖原（PG）纳米颗粒的结构-功能关系，并确定工程PG纳米颗粒介导的胶体系统的关键因素。生物基纳米材料在食品安全和营养、药物输送、个人护理和农业工程领域具有巨大的潜力。在该项目中，将从PG制备一类新的生物基树枝状多糖纳米材料，其具有30-100 nm的粒径和极高的分子密度。PG接枝上两亲性基团后可形成功能性胶体组装体。这些组件的突出特性是保护和递送亲脂性化合物，例如ω-3脂肪酸。该项目的目的是揭示天然PG，将从su 1突变玉米中提取，分馏，并进行化学和酶的修饰。功能化PG纳米颗粒的性能将被评估为它们实现增强的氧化稳定性和脂质的受控释放的能力。在此项目的支持下，将开发一个教学模块“碳水化合物设计的前沿”，并将其纳入PI的教育活动中。这一努力将极大地受益于参与的本科生和研究生，以及参加普渡大学年度碳水化合物短期课程的工业人员。在这个项目中，从玉米突变体中提取一种碳水化合物聚合物植物糖原（PG），并将其转化为功能性纳米颗粒。PG是由密集分布的分支制成的树枝状聚合物样多糖。基于植物糖原的纳米颗粒是可消化和可生物降解的，这使得它们能够在生理条件下递送生物活性化合物。例如，这些纳米颗粒可以保护脂质营养物（例如ω-3脂肪酸）免受氧化并在消化期间释放它们。在基础层面上，该项目将建立一个新的战略，以产生可持续的，环境友好的，经济的纳米结构，这将有利于食品安全和营养，药物输送，个人护理和农业工程领域。在本项目的支持下，将开发一个教学模块，介绍碳水化合物科学的前沿发展，包括碳水化合物修饰、食品安全和营养中的碳水化合物、基于碳水化合物的输送系统以及碳水化合物和绿色化学。该模块将被纳入校园的教育活动，用于培训本科生和研究生，以及参加普渡大学年度“碳水化合物短期课程”的工业人员。