SBIR Phase I: Commercialization and Scale Up of Ultra Low Fouling and Functionalizable Surface Coatings Based on Zwitterionic Polycarboxybetaine

这个小型企业创新研究（SBIR）一期项目旨在批量生产超低污染和功能化聚羧基甜菜碱（pCB）表面涂层。该方法旨在为两性离子羧基甜菜碱（CB）单体的经济高效、规模化生产开辟一条新途径。本文还将探讨一种制备高质量pCB表面涂层的新方法。该项目更广泛的商业影响将是为医疗设备和生物传感器、药物输送和消费品的应用提供两性离子材料/表面涂层技术的潜力。两性离子pCB不仅具有高度的非特异性蛋白质吸附能力，而且具有丰富的官能团，可以方便有效地通过常规化学方法固定生物分子。这使得pCB成为从诊断到给药的许多应用的理想选择。然而，制造pCB涂料的主要挑战之一是CB单体尚未商业化。该项目将通过开发一种大规模生产CB单体和pCB涂层的工艺来解决这一挑战。

This Small Business Innovation Research (SBIR) Phase I project aims to enable the batch production of ultra-low fouling and functionalizable polycarboxybetaine (pCB) surface coatings. The approach is to develop a new route for the cost-effective and large-scale production of the zwitterionic carboxybetaine (CB) monomers. A novel approach to prepare high quality pCB surface coatings will also be investigated.The broader/commercial impact of this project will be the potential to provide zwitterionic materials/surface coatings technology for applications in medical devices and biosensors, drug delivery and consumer products. Zwitterionic pCB is not only highly resistant to nonspecific protein adsorption, but also has abundant functional groups for the convenient and effective immobilization of biomolecules via conventional chemistry. This makes pCB an ideal choice for many applications from diagnostics to drug delivery. However, one of the major challenges in manufacturing of pCB coatings is that CB monomers are not commercially available. This project will address this challenge by developing a process for large-scale production of CB monomers and pCB coatings.