SFB 1021: RNA Viruses: RNA Metabolism, Host Response and Pathogenesis

SFB 1021：RNA 病毒：RNA 代谢、宿主反应和发病机制

• 批准号: 197785619
• 金额: --
• 依托单位: Philipps-Universität Marburg
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/197785619?language=en
• 关键词: SFB; 1021; RNA; Viruses; Metabolism

Virus infections remain a major threat to human and animal health. They have a huge impact on global economies and account for a substantial part of healthcare costs worldwide. RNA viruses are of particular interest because their replication machinery generally lacks proofreading activity and this can lead to the emergence of new pathogenic variants that transmit and replicate efficiently in new hosts. A prominent example for this phenomenon is the current COVID-19 pandemic which is caused by SARS-CoV-2, an RNA virus of the Coronaviridae family. The CRC 1021 investigates RNA viruses from different families including highly pathogenic (often zoonotic) viruses causing, for example, hemorrhagic fever, encephalitis or acute respiratory distress syndrome. Research in the CRC 1021 is performed in three major project areas: (i) synthesis and metabolism of viral RNA, (ii) viral factors determining pathogenicity of RNA viruses, and (iii) cellular responses to RNA virus infections and viral factors that counteract or help escape these cellular responses. The planned studies are based on the extensive RNA virus expertise available in this consortium including the availability, generation and use of genetically closely related viruses or nearly identical variants of the same virus (pathotypes) with fundamentally different pathogenic properties in specific hosts. The CRC 1021 employs a wide range of advanced methods and technologies (involving genomics and proteomics analyses) to study these viruses and to obtain new insight into fundamental aspects of RNA virus replication as well as the diverse and dynamic interactions of viral factors with cellular pathways and regulatory networks that operate at the virus-host interface and determine the pathogenicity of RNA viruses in humans and animals. To achieve these goals, the CRC 1021 takes a multi-disciplinary approach that brings together researchers with a highly complementary combination of technical skills and scientific expertise in the fields of RNA virology, cell biology, biochemistry, allergology, pharmaceutical sciences, and pharmacology.

病毒感染仍然是对人类和动物健康的主要威胁。它们对全球经济产生巨大影响，占全球医疗保健成本的很大一部分。RNA病毒特别令人感兴趣，因为它们的复制机制通常缺乏校对活性，这可能导致在新宿主中有效传播和复制的新致病变异的出现。这一现象的一个突出例子是目前由冠状病毒科RNA病毒SARS-CoV-2引起的COVID-19大流行。CRC 1021调查来自不同科的RNA病毒，包括引起出血热、脑炎或急性呼吸窘迫综合征等疾病的高致病性（通常是人畜共患）病毒。CRC 1021的研究在三个主要项目领域进行：(i)病毒RNA的合成和代谢，（ii）决定RNA病毒致病性的病毒因子，以及（iii）对RNA病毒感染的细胞反应以及抵消或帮助逃避这些细胞反应的病毒因子。计划中的研究是基于该联盟现有的广泛的RNA病毒专业知识，包括遗传上密切相关的病毒或在特定宿主中具有根本不同致病特性的相同病毒（病理型）的几乎相同变体的可获得性、产生和使用。CRC 1021采用广泛的先进方法和技术（包括基因组学和蛋白质组学分析）来研究这些病毒，并对RNA病毒复制的基本方面以及病毒因子与在病毒-宿主界面上运作的细胞途径和调节网络的多样化和动态相互作用获得新的见解，并确定RNA病毒在人类和动物中的致病性。为了实现这些目标，CRC 1021采用多学科方法，将RNA病毒学、细胞生物学、生物化学、过敏症学、制药科学和药理学等领域的技术技能和科学专业知识高度互补的研究人员聚集在一起。