Structure and function of ribosome biogenesis factors and their functional complexes with small ribosomal subunit RNAs and RNPs (B10)

核糖体生物发生因子及其与小核糖体亚基 RNA 和 RNP 的功能复合物的结构和功能 (B10)

• 批准号: 199695014
• 金额: --
• 依托单位: Institut für Molekulare Biowissenschaften
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/199695014?language=en
• 关键词: Structure; function; ribosome; biogenesis; factors

Ribosome assembly in eukaryotes is a highly complex process that requires the concerted action of ~ 200 ribosome assembly factors. Important structural and functional insights into their role in ribosome assembly can be obtained using their conserved archaeal homologs. We will investigate the structural basis for the functional interactions between ribosome assembly factors, ribosomal proteins and rRNA-elements involved in the late stages of small ribosomal subunit biogenesis with a focus on ribosomal proteins-chaperone systems. We will directly compare archaeal and eukaryotic systems to gain insight into the evolution of the ribosome assembly pathway.

真核生物中的核糖体组装是一个高度复杂的过程，需要约200个核糖体组装因子的协同作用。重要的结构和功能的见解，他们在核糖体组装中的作用，可以获得使用其保守的古细菌同源物。我们将研究核糖体组装因子，核糖体蛋白和rRNA-小核糖体亚基生物合成的后期阶段所涉及的元件之间的功能相互作用的结构基础，重点是核糖体蛋白伴侣系统。我们将直接比较古细菌和真核系统，以深入了解核糖体组装途径的进化。