SBIR Phase I: Novel Cost-Effective Enzyme Immobilization Technology for Sustainable Industrial Applications

这个小企业创新研究（SBIR）第一阶段项目的重点是设计一个强大的和低成本的酶固定系统，以提高生物催化过程的成本竞争力。缺乏一种通用的、合理的、负担得起的酶固定技术一直是生物催化在化学生产中广泛应用的一个巨大障碍，这种技术在减少化学工业中具有巨大的前景。美国的环境足迹。I期项目将通过开发一种强大且低成本的酶固定系统来消除这一障碍，该系统可广泛应用于许多不同的生物过程。S专有酶作为结合策略的基础。最终，该项目将开发出一种经济可行的系统，可以将任何酶固定在生物催化柱上，提高催化效率和寿命。这项研究的广泛/商业影响源于Arzeda拥有唯一经过验证的技术，可以设计具有自然界中不存在的催化机制的新型酶，并有助于解决生物精炼厂行业的许多最紧迫的需求：？开发生物催化途径以获得目前难以获得的可再生化学品和？通过延长酶的使用寿命和延长酶的使用寿命来提高盈利能力。因此，Arzeda认为这个项目的成功是增加生物催化应用的一种方式，从而增加其酶产品的市场。为了实现这一目标，Arzeda将应用其核心技术以及拟议的酶固定化策略来开发生物工艺，从而从生物质中获得高价值的可再生化学品。

This Small Business Innovation Research (SBIR) Phase I project focuses on the design of a robust and low-cost enzyme immobilization system to increase the cost-competitiveness of bio-catalytic processes. The lack of a universal, sound, and affordable enzyme immobilization technique has been a large barrier to widespread deployment of bio-catalysis for chemical production, which hold immense promise for reducing the chemical industry?s environmental footprint. This Phase I project will lift this barrier by developing a robust and low-cost enzyme immobilization system with broad application for many different bioprocesses using one of Arzeda Corp.?s proprietary enzymes as the basis of the binding strategy. Ultimately, this project will lead to an economically viable system for immobilization of any enzyme on a bio-catalysis column with increased catalytic efficiency and longevity.The broader/commercial impacts of this research result from the fact that Arzeda has the only proven technology to design novel enzymes with catalytic machinery not existing in nature And is helping address many of the most pressing needs of the bio-refinery industry:? Developing bio-catalytic routes to currently inaccessible renewable chemicals and? Increasing profitability through extending enzyme lifetime and increasing enzyme lifetime.As such, Arzeda sees the success of this project as a way to increase the adoption of bio-catalysis and thereby increase the market for its enzyme products. To achieve this, Arzeda will apply its core technology along with the proposed enzyme immobilization strategy to develop bioprocesses enabling high value, renewable chemicals from biomass.