SBIR Phase I: Novel Cost-Effective Enzyme Immobilization Technology for Sustainable Industrial Applications

SBIR 第一阶段：用于可持续工业应用的新型经济高效的酶固定化技术

• 批准号: 1047429
• 负责人: Eric Althoff
• 金额: $ 15万
• 依托单位: ARZEDA Corp.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1047429&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Cost; Effective

This Small Business Innovation Research (SBIR) Phase I project focuses on the design of a robust and low-cost enzyme immobilization system to increase the cost-competitiveness of bio-catalytic processes. The lack of a universal, sound, and affordable enzyme immobilization technique has been a large barrier to widespread deployment of bio-catalysis for chemical production, which hold immense promise for reducing the chemical industry?s environmental footprint. This Phase I project will lift this barrier by developing a robust and low-cost enzyme immobilization system with broad application for many different bioprocesses using one of Arzeda Corp.?s proprietary enzymes as the basis of the binding strategy. Ultimately, this project will lead to an economically viable system for immobilization of any enzyme on a bio-catalysis column with increased catalytic efficiency and longevity.The broader/commercial impacts of this research result from the fact that Arzeda has the only proven technology to design novel enzymes with catalytic machinery not existing in nature And is helping address many of the most pressing needs of the bio-refinery industry:? Developing bio-catalytic routes to currently inaccessible renewable chemicals and? Increasing profitability through extending enzyme lifetime and increasing enzyme lifetime.As such, Arzeda sees the success of this project as a way to increase the adoption of bio-catalysis and thereby increase the market for its enzyme products. To achieve this, Arzeda will apply its core technology along with the proposed enzyme immobilization strategy to develop bioprocesses enabling high value, renewable chemicals from biomass.

这个小型企业创新研究(SBIR)第一阶段项目的重点是设计一个强大的、低成本的酶固定化系统，以提高生物催化过程的成本竞争力。缺乏一种普遍、完善和负担得起的酶固定化技术一直是生物催化在化工生产中广泛应用的一大障碍，这为减少化学工业的环境足迹带来了巨大的希望？S。这个第一阶段的项目将通过开发一种强大且低成本的酶固定化系统来消除这一障碍，该系统广泛应用于许多不同的生物过程，使用Arzeda公司的S专利酶作为结合策略的基础。最终，该项目将带来一种经济上可行的系统，可以将任何酶固定在生物催化柱上，从而提高催化效率和寿命。这项研究的更广泛/更广泛的商业影响来自以下事实：Arzeda拥有唯一经过验证的技术，可以用自然界中不存在的催化机械设计新型酶，并正在帮助解决生物炼油业许多最紧迫的需求：开发生物催化路线以获取目前无法获得的可再生化学品，以及？通过延长酶寿命和延长酶寿命来提高盈利能力。因此，Arzeda将该项目的成功视为增加生物催化的采用，从而增加其酶产品的市场。为了实现这一目标，Arzeda将应用其核心技术和拟议的酶固定化策略来开发生物工艺，使高价值的可再生化学物质能够从生物质中获得。