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US-South Africa DDEP: Efficient Processing of Polydisperse Particulate Mixtures

US-South Africa DDEP: Efficient Processing of Polydisperse Particulate Mixtures
美国-南非 DDEP:多分散颗粒混合物的高效加工
批准号:
1048843
负责人:
Benjamin Glasser
金额:
$1.5万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-12-01 至 2012-11-30

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项目成果

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中文摘要
翻译
智力价值:微粒或颗粒状物质在我们的日常生活中随处可见,从我们吃的食物,到我们开车的道路,再到我们服用的药物。很难找到一种商业产品,在混合并转化为最终形式之前,在某种程度上不是不同的、不同的颗粒的集合。然而,尽管颗粒材料普遍存在,但与流体设备相比,它们的处理单元的运行水平很低。因此,颗粒处理厂效率低下,经常停工,浪费过多,所有这些都导致了更高的产品成本。通常,经验法则被用来限制这些问题,但这些并不能可靠地预测和防止处理问题的发生。更理想的方法是能够从基本原理、材料特性和小规模实验室测试中定量预测流动行为和离析率,然后设计相应的工艺,以限制对性能和产品均匀性的有害影响。一个多学科的研究团队对于首先表征颗粒材料的基本性质,然后将这些知识扩展到工业规模的有效操作至关重要。罗格斯大学的Benjamin Glasser教授和Matthew Metzger先生与南非威特沃特斯兰德大学(WITS)的Diane Hildebrandt教授的研究小组的合作将独特地将颗粒材料的基本知识与大规模设计高效颗粒操作的能力联系起来。这些问题的核心是缺乏对粒子在驱动力作用下的行为的基本理解,这极大地阻碍了复制和扩大粒子过程的尝试。建议的博士论文增强项目将侧重于发展一个基本的理解,为什么颗粒状材料倾向于分离,或解混。在常见的颗粒系统中,对不同粗糙度的多分散颗粒的流动进行研究,将有助于为各种颗粒混合物的离析潜力的智能决策奠定基础。随后的分析将确定操作制度,以尽量减少工业操作期间的颗粒分离。更广泛的影响:这项合作将培育一个沟通渠道,促进两个在各自领域的领先研究小组之间正在进行和未来的交流。罗格斯大学(Rutgers University)的Glasser教授的团队因其基础性工作而获得国际认可,这些工作揭示了颗粒状材料的分离趋势与尺寸、密度和表面特性差异引起的不稳定性之间的联系。Hildebrandt教授吗?他在WITS大学的团队提供了互补的专业知识,从系统的角度将基础知识融入高效流程的设计中。总的来说,这一合作将把国际知名的科学家和单一大学所没有的专业知识联系起来。拟议的研究将制定一个框架,以确定颗粒单元操作的最佳操作条件,以减少颗粒处理操作中经常遇到的产品故障和低效率的发生。该奖项由美国国家科学基金会国际科学与工程办公室资助。
英文摘要
Intellectual Merit: Particulate, or granular, materials are encountered throughout our daily lives, ranging from the food we eat, to the roads we drive on, to the medicines we take. It is challenging to find a commercial product that at some point was not a collection of differing, distinct particles before it was mixed and transformed into its final form. Yet, despite the prevalence of particulate materials, their processing units operate at meager levels compared to their fluid counterparts. As a result, particulate processing plants suffer from poor efficiency, frequent shutdowns and excess waste, all contributing to higher product cost. Often, rules-of-thumb have been used to limit these problems, but these have not reliably predicted and prevented processing problems from occurring. A more desirable approach is the ability to quantitatively predict flow behavior and segregation rates from fundamental principles, material properties and small-scale laboratory tests, and then to engineer processes accordingly to limit detrimental effects on performance and product uniformity. A multidisciplinary research team is critical to first characterize the fundamental nature of granular materials and then extend that knowledge to efficient operation at industrial scale. Collaboration among Professor Benjamin Glasser and Mr. Matthew Metzger at Rutgers University with the research group of Professor Diane Hildebrandt at the University of the Witwatersrand (WITS) in South Africa will uniquely connect the basic knowledge of granular materials with ability to design efficient granular operations at scale. At the core of these issues is the lack of a fundamental understanding of how particles behave when subject to a driving force, which significantly hampers attempts to reproduce and scale-up particulate processes. The proposed Doctoral Dissertation Enhancement Project will focus on developing a fundamental understanding of why granular materials tend to segregate, or de-mix. Investigations of the flow of polydisperse particles of varying degrees of roughness in commonly encountered granular systems will assist in building the foundation for intelligent decision making about the segregation potential of a variety of particulate mixtures. Subsequent analysis will determine operation regimes to minimize particulate segregation during industrial operation. Broader Impact: The collaboration will nurture a conduit of communication that will facilitate on-going and future exchanges between the two leading research groups in their respective fields. Prof. Glasser's group at Rutgers University is internationally recognized for foundational works exposing links between the tendency of granular materials to segregate and instabilities caused by differences in size, density and surface properties. Prof. Hildebrandt?s group at WITS University offers complementary expertise in incorporating elementary knowledge into the design of efficient processes from a systems perspective. Collectively, the collaboration will connect internationally-renowned scientists and expertise not found at a single university. The proposed studies will develop a framework to determine optimal operation conditions for granular unit operations to decrease the occurrence of product failures and inefficiencies frequently encountered during particulate processing operations.This award has been funded by NSF's Office of International Science and Engineering.
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会议论文
PFI:AIR-RA: Commercializing Pharmaceutical Process Modeling for Continuous Manufacturing
  • 批准号:
    1537197
  • 项目类别:
    Standard Grant
  • 资助金额:
    $80.0万
  • 财政年份:
    2015
  • 负责人:
    Benjamin Glasser
  • 依托单位:
PFI:AIR - TT: Manufacturing of Pharmaceuticals by Fluidized Bed Impregnation of Active Pharmaceutical Ingredients onto Porous Carriers
  • 批准号:
    1444903
  • 项目类别:
    Standard Grant
  • 资助金额:
    $20.0万
  • 财政年份:
    2014
  • 负责人:
    Benjamin Glasser
  • 依托单位:
GOALI: Segregation of Sheared Particle Mixtures
  • 批准号:
    0730767
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $0.0万
  • 财政年份:
    2007
  • 负责人:
    Benjamin Glasser
  • 依托单位:
US-South Africa Planning Visit: Synthesis of Carbon Nanotubes using Continuous Chemical Vapor Deposition
  • 批准号:
    0617575
  • 项目类别:
    Standard Grant
  • 资助金额:
    $0.9万
  • 财政年份:
    2006
  • 负责人:
    Benjamin Glasser
  • 依托单位:
海外基金