RUI: Fundamental Studies on the Separation Mechanisms of Porous Polymer Monoliths

RUI：多孔聚合物整体分离机理的基础研究

• 批准号: 1055516
• 负责人: Laura Hunsicker-Wang
• 金额: $ 33.5万
• 依托单位: Trinity University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1055516&HistoricalAwards=false
• 关键词: RUI; Fundamental; Studies; Separation; Mechanisms

Professor Michelle M. Bushey of Trinity University is supported by the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry to conduct a fundamental study of the interactions of analytes and the mobile phase with organic polymer monolith stationary phases in HPLC and capillary electrochromatography (CEC). The objective is to derive a basic understanding of the separation mechanisms with organic polymer monolith stationary phases. Thermodynamic properties and diffusion coefficients will be measured as a function of retention factor for different analytes, different mobile phases and different acrylate and methacrylate monolithic polymers. A thorough understanding of these interactions will impact the development of efficient stationary phases for practical chromatographic separations. Modeling of chromatographic separations with conventional stationary phases has resulted in great improvement in separation performance. The lack of a parallel basic understanding of chromatography with polymer monolith stationary phases hampered the development and limited the broad acceptance of these unique analytical separation media. Undergraduate students will be trained in analytical separation science and technology in an ethnically diverse undergraduate institution.

Michelle M. Trinity University的Bushey得到了化学系化学测量和成像（CMI）项目的支持，对HPLC和毛细管电色谱（CEC）中分析物和移动的相与有机聚合物整体固定相的相互作用进行了基础研究。 其目的是获得一个基本的理解与有机聚合物整体固定相的分离机制。 热力学性质和扩散系数将被测量为不同的分析物，不同的移动的相和不同的丙烯酸酯和甲基丙烯酸酯单体聚合物的保留因子的函数。 对这些相互作用的透彻理解将影响用于实际色谱分离的高效固定相的开发。 传统固定相色谱分离模型的建立极大地改善了色谱分离性能。缺乏对聚合物整体柱固定相色谱的平行基本理解阻碍了这些独特的分析分离介质的发展并限制了其广泛接受。 本科生将在一个种族多元化的本科院校接受分析分离科学和技术方面的培训。