CAREER: Metal-Free Carbonyl Additions to Carboxylic Acids Using Diarylphosphine Oxides

事业：使用二芳基氧化膦对羧酸进行无金属羰基加成

• 批准号: 1056242
• 负责人: Brandon Ashfeld
• 金额: $ 55万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1056242&HistoricalAwards=false
• 关键词: CAREER; Metal; Free; Carbonyl; Additions

The Chemical Synthesis Program of the Chemistry Division supports the work of Professor Brandon L. Ashfeld at the University of Notre Dame toward the design and development of new phosphorus mediated synthetic strategies for the direct conversion of carboxylic acids to ketones. This research uses an alkyl phosphorus-to-carbon ligand transfer that enables the formation of new carbon-carbon bonds with high levels of chemoselectivity and effectively allows for an operationally simple and efficient approach toward synthetic targets through unconventional bond constructs. This study expands the role of carboxylic acids and phosphorus reagents in synthesis and introduces new and exciting strategies for complex molecule synthesis.The long term impact of this research program is the development of synthetic strategies that enable the construction of new and complex compounds useful for scientific research pharmaceutical industry. The educational component of this CAREER award describes a series of outreach initiatives to inspire secondary students to pursue careers in the physical sciences, the development of an undergraduate course in energy sustainability, and the design of an interactive, web-based workbook to serve as a valuable resource for students and educators of chemistry. The combined research and education components constitute the foundation of this training program, and address the fundamental issues of safety, environmental friendliness, energy conservation, and cost of chemical research. Recruitment and training of undergraduate students, women, and under-represented minorities to chemistry, and the physical sciences, is a key aspect of this multi-faceted program.

化学系的化学合成项目支持布兰登教授的工作。Ashfeld博士在圣母大学致力于设计和开发新的磷介导的合成策略，用于将羧酸直接转化为酮。 该研究使用烷基磷-碳配体转移，能够形成具有高水平化学选择性的新碳-碳键，并有效地允许通过非常规键结构实现合成目标的操作简单有效的方法。 本研究扩展了羧酸和磷试剂在合成中的作用，并介绍了复杂分子合成的新的和令人兴奋的策略。本研究计划的长期影响是开发合成策略，使新的和复杂的化合物的构建对科学研究制药工业有用。 该职业奖的教育部分描述了一系列外展计划，以激励中学生追求物理科学的职业生涯，能源可持续性本科课程的开发，以及交互式，基于网络的工作簿的设计，作为学生和化学教育工作者的宝贵资源。研究和教育相结合的组成部分构成了这个培训计划的基础，并解决安全，环境友好，节能和化学研究成本的基本问题。招募和培养本科生，妇女和代表性不足的少数民族化学和物理科学，是这个多方面计划的一个关键方面。