CAREER: Metal-Free Carbonyl Additions to Carboxylic Acids Using Diarylphosphine Oxides

化学部门的化学合成项目支持圣母大学的Brandon L. Ashfeld教授设计和开发新的磷介导合成策略，用于将羧酸直接转化为酮类。本研究使用烷基磷到碳配体转移，能够形成具有高水平化学选择性的新碳-碳键，并有效地允许通过非常规键构建实现简单有效的合成目标方法。本研究扩展了羧酸和磷试剂在合成中的作用，并为复杂分子的合成引入了新的和令人兴奋的策略。这项研究计划的长期影响是合成策略的发展，使新的和复杂的化合物的建设对科学研究和制药工业有用。CAREER奖的教育部分描述了一系列外展活动，以激励中学生从事物理科学的职业，开发能源可持续发展的本科课程，以及设计一个交互式的基于网络的工作手册，作为化学学生和教育者的宝贵资源。研究和教育相结合的组成部分构成了该培训计划的基础，并解决了安全，环境友好，节能和化学研究成本的基本问题。招收和培训化学和物理科学专业的本科生、女性和代表性不足的少数族裔，是这个多面项目的一个关键方面。

The Chemical Synthesis Program of the Chemistry Division supports the work of Professor Brandon L. Ashfeld at the University of Notre Dame toward the design and development of new phosphorus mediated synthetic strategies for the direct conversion of carboxylic acids to ketones. This research uses an alkyl phosphorus-to-carbon ligand transfer that enables the formation of new carbon-carbon bonds with high levels of chemoselectivity and effectively allows for an operationally simple and efficient approach toward synthetic targets through unconventional bond constructs. This study expands the role of carboxylic acids and phosphorus reagents in synthesis and introduces new and exciting strategies for complex molecule synthesis.The long term impact of this research program is the development of synthetic strategies that enable the construction of new and complex compounds useful for scientific research pharmaceutical industry. The educational component of this CAREER award describes a series of outreach initiatives to inspire secondary students to pursue careers in the physical sciences, the development of an undergraduate course in energy sustainability, and the design of an interactive, web-based workbook to serve as a valuable resource for students and educators of chemistry. The combined research and education components constitute the foundation of this training program, and address the fundamental issues of safety, environmental friendliness, energy conservation, and cost of chemical research. Recruitment and training of undergraduate students, women, and under-represented minorities to chemistry, and the physical sciences, is a key aspect of this multi-faceted program.