New Reactions of Organic Peroxides

有机过氧化物的新反应

• 批准号: 1057982
• 负责人: Patrick Dussault
• 金额: $ 42万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057982&HistoricalAwards=false
• 关键词: New; Reactions; Organic; Peroxides

Professor Patrick Dussault of the University of Nebraska-Lincoln is supported by the Chemical Synthesis program in the Division of Chemistry to conduct research related to new reactions of organic peroxides. The research focuses on two areas: 1) Mild methods to generate the first excited state of oxygen, often known as "singlet oxygen", through the chemical decomposition of readily available 1,1-dihydroperoxides; and, 2) Investigations of the new methods for formation of carbon-oxygen bonds based upon application of organic peroxides as electrophiles towards carbon-based nucleophiles. This research may lead to much milder and more efficient methods for the rapid and/or large-scale generation of singlet oxygen, an important chemical oxidant which is also the power source for large-scale industrial and military lasers. The development of new methods for introduction of carbon-oxygen bonds is of great importance for industries and disciplines that need to prepare new organic molecules; this includes the pharmaceutical and agrochemical industries. Moreover, this project may enable the synthesis of classes of molecules not generally available at present, opening the doors to new technologies and yet unimagined classes of organic materials and polymers. The research will offer an outstanding opportunity for training of undergraduates and graduate students as future members of the nation's technical workforce. The training will be focused on organic chemistry (both experimental and literature components) but will also include strong components in teamwork, communication, mentoring, and research leadership.

内布拉斯加大学林肯分校的帕特里克杜索教授得到化学系化学合成项目的支持，进行与有机过氧化物新反应有关的研究。 该研究集中在两个领域：1）温和的方法来产生氧的第一激发态，通常被称为“单线态氧”，通过容易获得的1，1-二氢过氧化物的化学分解;和，2）基于有机过氧化物作为亲电试剂对碳基亲核试剂的应用，研究形成碳-氧键的新方法。 这项研究可能会导致更温和和更有效的方法，用于快速和/或大规模产生单线态氧，一种重要的化学氧化剂，也是大规模工业和军用激光器的电源。 开发引入碳-氧键的新方法对于需要制备新有机分子的行业和学科具有重要意义;这包括制药和农业化学工业。 此外，该项目可能使目前尚未普遍获得的分子类别的合成成为可能，为新技术和尚未想象到的有机材料和聚合物类别打开大门。这项研究将为培养本科生和研究生成为国家技术劳动力的未来成员提供一个极好的机会。 培训将侧重于有机化学（实验和文献部分），但也将包括团队合作，沟通，指导和研究领导的强大组件。