New Reactions of Organic Peroxides

内布拉斯加大学林肯分校的Patrick Dussault教授在化学系化学合成项目的支持下进行与有机过氧化物新反应相关的研究。研究主要集中在两个方面：1)温和的方法产生氧的第一激发态，通常被称为“单线态氧”，通过化学分解容易获得的1,1-二氢过氧化物；2)基于有机过氧化物作为亲电试剂应用于碳基亲核试剂的碳氧键形成新方法的研究。单线态氧是一种重要的化学氧化剂，也是大型工业和军事激光器的动力源，这项研究可能会导致更温和和更有效的方法来快速和/或大规模产生单线态氧。开发引入碳氧键的新方法对于需要制备新的有机分子的行业和学科具有重要意义；这包括制药和农用化学工业。此外，该项目可能使合成目前不常见的分子类别，为新技术和尚未想象的有机材料和聚合物类别打开大门。这项研究将为培养本科生和研究生成为国家技术劳动力的未来成员提供一个绝佳的机会。培训将侧重于有机化学（包括实验和文献部分），但也将包括团队合作、沟通、指导和研究领导方面的重要内容。

Professor Patrick Dussault of the University of Nebraska-Lincoln is supported by the Chemical Synthesis program in the Division of Chemistry to conduct research related to new reactions of organic peroxides. The research focuses on two areas: 1) Mild methods to generate the first excited state of oxygen, often known as "singlet oxygen", through the chemical decomposition of readily available 1,1-dihydroperoxides; and, 2) Investigations of the new methods for formation of carbon-oxygen bonds based upon application of organic peroxides as electrophiles towards carbon-based nucleophiles. This research may lead to much milder and more efficient methods for the rapid and/or large-scale generation of singlet oxygen, an important chemical oxidant which is also the power source for large-scale industrial and military lasers. The development of new methods for introduction of carbon-oxygen bonds is of great importance for industries and disciplines that need to prepare new organic molecules; this includes the pharmaceutical and agrochemical industries. Moreover, this project may enable the synthesis of classes of molecules not generally available at present, opening the doors to new technologies and yet unimagined classes of organic materials and polymers. The research will offer an outstanding opportunity for training of undergraduates and graduate students as future members of the nation's technical workforce. The training will be focused on organic chemistry (both experimental and literature components) but will also include strong components in teamwork, communication, mentoring, and research leadership.