STTR Phase II: Polyaniline Nanofiber Urinary Tract Infection Biosensor-A Multi-Functional Bioresponsive Material

STTR二期：聚苯胺纳米纤维尿路感染生物传感器——多功能生物响应材料

• 批准号: 1058598
• 负责人: Christina Baker
• 金额: $ 50万
• 依托单位: Fibron Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058598&HistoricalAwards=false
• 关键词: STTR; Phase; II; Polyaniline; Nanofiber

This Small Business Technology Transfer Research (STTR) Phase II project is for the development of an inexpensive, rapid, high-accuracy test for the detection and identification of the pathogens that cause urinary tract infections (UTIs). Currently, UTI diagnosis is an expensive and lengthy process that often results in patients given unnecessary or ineffective antibiotics. This pathogen detection system utilizes highly dispersible polyaniline nanofibers that bind to markers in urine to generate a visible change in solution with the appearance of nanofiber aggregates. Versions of this test will be optimized for UTI detection, leukocyte detection and pathogen identification. An array of nanofibers functionalized for detection of different bacterial markers will be used for demonstration of pathogen identification. The broader impacts of this research are increased access to accurate tests for pathogen identification, healthcare cost reduction and reduction of antibiotic resistance. The low cost and ease of this test will allow patients to get diagnosed expeditiously, and then treated properly using species-directed medication rather than broad antibiotic coverage. This will have a great impact on decelerating the rise of antibiotic resistance. This test also has potential with future development in other target detection applications such as food/water testing and meningitis. Researchers may also benefit from this development as an alternative to more expensive and slower routes for identification of pathogens like culture. The overall cost reduction associated with this method of marker detection may also increase access to better infection diagnosis and treatment to lower income populations and patients in third world countries.

这个小企业技术转让研究（STTR）第二阶段项目是为了开发一种廉价，快速，高准确度的检测和鉴定导致尿路感染（UTI）的病原体的测试。目前，UTI诊断是一个昂贵而漫长的过程，经常导致患者服用不必要或无效的抗生素。该病原体检测系统利用高度可分散的聚苯胺纳米纤维，其与尿液中的标记物结合，以产生溶液中的可见变化，并出现可降解的聚集体。该检测的版本将针对UTI检测、白细胞检测和病原体鉴定进行优化。将使用用于检测不同细菌标志物的功能化纳米纤维阵列来证明病原体鉴定。这项研究的更广泛的影响是增加了获得准确的病原体鉴定测试，降低医疗成本和减少抗生素耐药性。这种测试的低成本和简便性将使患者能够迅速得到诊断，然后使用针对物种的药物而不是广泛的抗生素覆盖进行适当的治疗。这将对减缓抗生素耐药性的上升产生重大影响。该测试在其他目标检测应用（如食品/水测试和脑膜炎）的未来发展中也具有潜力。研究人员也可能受益于这一发展，作为一种替代更昂贵和更慢的病原体鉴定途径，如培养。与这种标记物检测方法相关的总体成本降低也可以增加第三世界国家低收入人群和患者获得更好的感染诊断和治疗的机会。