Rho-GTPase-dependent plasmacytoid dendritic cell seeding, retention and recruitment in vivo (A06)

Rho-GTPase 依赖性浆细胞样树突状细胞体内接种、保留和募集 (A06)

• 批准号: 200804696
• 金额: --
• 依托单位: Forschungsbereich Immunologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200804696?language=en
• 关键词: Rho; GTPase; dependent; plasmacytoid; dendritic

We propose a new scheme of pDC-migration: seeding from blood to peripheral tissues in steady-state and recruitment to site of inflammation by appropriate stimuli with peripheral tissues as pDC-reservoirs. First results indicate that pDCs are controlled by the Rho-family GTPase Cdc42, as Cdc42-ko pDCs display impaired recruitment. A specific focus will be given to the kinetic, route and interac-tion sequences of pDCs with other cells before they re-renter the circulation. Analyses of molecular mechanisms of turnover, proliferative capacity and homing will reveal the involvement of Cdc42 in pDC development, function and distribution.

我们提出了一种新的方案的pDC迁移：从血液中接种到外周组织中的稳态和招聘的炎症部位与外周组织作为pDC水库适当的刺激。第一个结果表明，pDC由Rho家族GT3 Cdc 42控制，因为Cdc 42-ko pDC显示受损的募集。一个特定的焦点将给予动力学，路径和相互作用序列的pDC与其他细胞之前，他们重新进入循环。对周转、增殖能力和归巢的分子机制的分析将揭示Cdc 42参与pDC的发育、功能和分布。