Helicobacter pylori - CEACAM interaction, gastric leukocyte recruitment and local immunomodulation (B05)

幽门螺杆菌 - CEACAM 相互作用、胃白细胞募集和局部免疫调节 (B05)

• 批准号: 200807036
• 金额: --
• 依托单位: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200807036?language=en
• 关键词: Helicobacter; pylori; CEACAM; interaction; gastric

Helicobacter pylori may cause peptic ulcer or gastric cancer. The bacteria use CEACAM host cell receptors to inject its CagA toxin. H. pylori does not interact with murine CEACAMs, which prevents cellular signaling and subsequent chemokine release in murine leukocytes, preventing a strong recruitment of immune cells in the gastric mucosa. We aim to functionally characterize murine leukocytes expressing human CEACAMs and investigate their interaction with H. pylori in vitro and in vivo using biochemical and novel multiphoton intravital microscopy to better understand the persistence mechanisms of H. pylori in the host.

幽门螺杆菌可能导致消化性溃疡或胃癌。这种细菌使用CEACAM宿主细胞受体来注射其CagA毒素。H.幽门螺杆菌不与鼠CEACAMs相互作用，这阻止了细胞信号传导和随后的鼠白细胞中的趋化因子释放，阻止了胃粘膜中免疫细胞的强烈募集。我们的目的是功能性地表征表达人CEACAMs的小鼠白细胞，并研究它们与H. pylori在体外和体内使用生物化学和新的多光子活体显微镜，以更好地了解H.宿主体内的幽门螺杆菌