SFB 1035: Control of Protein Function by Conformational Switching

SFB 1035：通过构象转换控制蛋白质功能

• 批准号: 201302640
• 金额: --
• 依托单位: Ludwig-Maximilians-Universität München (LMU)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/201302640?language=en
• 关键词: SFB; 1035; Control; Protein; Function

Structural plasticity and conformational dynamics are hallmarks of proteins. Delineating the mechanisms of conformational switches in proteins, tightly controlled by various factors and processes, is key to unravel the principles that shape our protein universe. The CRC1035 combines researchers with complementary expertise in advanced biochemical and biophysical methods and employs interdisciplinary approaches to determine the underlying molecular mechanisms. Analysis of model systems has provided an understanding of basic principles of conformational switches. The progress achieved forms the basis for analysing the specific mechanisms of conformational switching in the regulation of protein function in medically relevant assemblies and systems linked to (patho)physiological conditions.

结构可塑性和构象动力学是蛋白质的标志。阐明受各种因素和过程严格控制的蛋白质构象转换机制是解开塑造蛋白质宇宙的原理的关键。CRC1035将研究人员与先进的生物化学和生物物理方法的互补专业知识相结合，并采用跨学科方法来确定潜在的分子机制。模型系统的分析提供了构象开关的基本原理的理解。所取得的进展形成的基础上，分析特定的机制，构象转换的蛋白质功能的调节在医学相关的组件和系统连接到（病理）生理条件。