SFB 1035: Control of Protein Function by Conformational Switching

结构可塑性和构象动力学是蛋白质的特征。描述蛋白质构象转换的机制，受到各种因素和过程的严格控制，是解开塑造我们蛋白质宇宙的原理的关键。CRC1035结合了在高级生化和生物物理方法方面具有互补专业知识的研究人员，并采用跨学科方法来确定潜在的分子机制。通过对模型系统的分析，我们了解了构象开关的基本原理。所取得的进展为分析与(病理)生理条件相关的医疗相关组件和系统中蛋白质功能调节中的构象转换的具体机制奠定了基础。

Structural plasticity and conformational dynamics are hallmarks of proteins. Delineating the mechanisms of conformational switches in proteins, tightly controlled by various factors and processes, is key to unravel the principles that shape our protein universe. The CRC1035 combines researchers with complementary expertise in advanced biochemical and biophysical methods and employs interdisciplinary approaches to determine the underlying molecular mechanisms. Analysis of model systems has provided an understanding of basic principles of conformational switches. The progress achieved forms the basis for analysing the specific mechanisms of conformational switching in the regulation of protein function in medically relevant assemblies and systems linked to (patho)physiological conditions.