The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence

光子免疫芯片：使用光波导多色荧光检索单个酶联免疫吸附测定 (ELISA) 阵列单元

• 批准号: LP0990871
• 负责人: Dr Mattias Aslund
• 金额: $ 11.08万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-03-09 至 2013-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0990871
• 关键词: photonic; immunochip; retrieving; individual; Enzyme

Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the commonly used ELISA technology. This will be achieved by developing a novel optical integrated waveguide array supporting a large range of distributed tests, including several based on a novel multi-colour detection scheme. This massively parallel approach will underpin a new generation of low-cost, efficient diagnostic tests.

提高体外免疫诊断测试的敏感性和可得性是开发检测传染病、癌症、过敏和自身免疫性疾病的实时高效工具的关键目标。目的是通过减少背景噪声来提高这些测试的灵敏度，背景噪声一直是常用ELISA技术的一个特点。这将通过开发一种新型的光学集成波导阵列来实现，该阵列支持大范围的分布式测试，包括几种基于新型多色检测方案的测试。这种大规模并行的方法将为新一代低成本、高效的诊断测试奠定基础。