International Collaboration in Chemistry: Catalytic Atom-Economical Aromatic Substitution via Radicals

化学结构、动力学和机理项目支持利哈伊大学的R.A.弗劳尔斯教授的“化学国际合作”项目。外国研究人员是来自德国的A.Gansäuer教授，他对合作项目的贡献将得到德国科学基金会(DFG)的支持。研究人员将开发用于芳香族化合物官能化的金属催化剂，通过使用碳心自由基进行均裂取代。碳-碳键的形成至关重要，新的发展将有助于有机化合物，特别是芳香族化合物的可持续合成。德国的PI提供了在有机合成中使用自由基催化的专业知识，美国的PI在有机反应的机理研究中提供了专业知识。Flowers和Gansäuer教授将详细了解基于钛并茂金属的催化自由基反应，为芳烃功能化提供高效和选择性的方法。芳烃是许多化学商品产品的中心，如苯乙烯。这项工作的目标之一是提供光学富集芳基-2-丙醇，它们构成合成非类固醇抗炎药(NSAIDs)的基石。国际团队将包括本科生和研究生，他们将接受标准有机化学实验室通常不包括的技术方面的多学科培训。

The Chemical Structure, Dynamics and Mechanisms Program supports Professor R. A. Flowers from Lehigh University on an "International Collaboration in Chemistry" project. The foreign investigator is Professor A. Gansäuer from Germany, whose contribution to the collaborative project will be supported by the German Science Foundation (DFG). The researchers will develop metal catalysts for the functionalization of aromatic compounds via homolytic substitutions employing carbon centered radicals. The formation of C-C bonds is of fundamental importance and new developments will contribute to the sustainable synthesis of organic compounds, in particular aromatic compounds. The German PI provides expertise in the use of radical catalysis in organic synthesis, the US PI in mechanistic studies of organic reactions. Professors Flowers and Gansäuer will pursue a detailed understanding of catalytic titanocene based radical reactions to provide efficient and selective approaches for arene functionalization. Arenes are at the center of many chemical commodity products such as styrene. One of the goals of this work is to furnish optically enriched aryl-2-propanols, which form the building blocks for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDS). The international team will include undergraduate and graduate students who will receive multidisciplinary training in techniques not typically covered in standard organic chemistry laboratories.