International Collaboration in Chemistry: Catalytic Atom-Economical Aromatic Substitution via Radicals

国际化学合作：通过自由基进行催化原子经济芳香族取代

• 批准号: 1123815
• 负责人: Robert Flowers
• 金额: $ 40.5万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1123815&HistoricalAwards=false
• 关键词: International; Collaboration; Chemistry; Catalytic; Atom

The Chemical Structure, Dynamics and Mechanisms Program supports Professor R. A. Flowers from Lehigh University on an "International Collaboration in Chemistry" project. The foreign investigator is Professor A. Gansäuer from Germany, whose contribution to the collaborative project will be supported by the German Science Foundation (DFG). The researchers will develop metal catalysts for the functionalization of aromatic compounds via homolytic substitutions employing carbon centered radicals. The formation of C-C bonds is of fundamental importance and new developments will contribute to the sustainable synthesis of organic compounds, in particular aromatic compounds. The German PI provides expertise in the use of radical catalysis in organic synthesis, the US PI in mechanistic studies of organic reactions. Professors Flowers and Gansäuer will pursue a detailed understanding of catalytic titanocene based radical reactions to provide efficient and selective approaches for arene functionalization. Arenes are at the center of many chemical commodity products such as styrene. One of the goals of this work is to furnish optically enriched aryl-2-propanols, which form the building blocks for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDS). The international team will include undergraduate and graduate students who will receive multidisciplinary training in techniques not typically covered in standard organic chemistry laboratories.

化学结构，动力学和机制计划支持教授R。A.来自利哈伊大学的鲜花参加了“化学国际合作”项目。外国研究者是A教授。来自德国的Gansäuer，他对合作项目的贡献将得到德国科学基金会（DFG）的支持。研究人员将开发金属催化剂，用于芳香族化合物的功能化，通过使用碳中心自由基的均裂取代。C-C键的形成具有根本的重要性，并且新的发展将有助于有机化合物，特别是芳香族化合物的可持续合成。德国PI提供在有机合成中使用自由基催化的专业知识，美国PI提供有机反应的机理研究。教授花和Gansäuer将追求催化二茂钛为基础的自由基反应的详细了解，为芳烃官能化提供有效和选择性的方法。芳烃是苯乙烯等许多化学商品的核心。本工作的目标之一是提供光学富集的芳基-2-丙醇，其形成用于合成非甾体抗炎药（NSAIDS）的构建块。国际团队将包括本科生和研究生，他们将接受标准有机化学实验室通常不涉及的技术的多学科培训。