GRK 1427: Food Constituents as Triggers of Nuclear Receptor-mediated Intestinal Signalling

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Public concern about food safety calls for the development of a reliable data base for the impact of food constituents on human health. The Research Training Group aims at linking a contribution to this demand with high impact basic research in biomedicine. Current knowledge about cell cycle, proliferation and cell death suggests that the mechanisms of action of well-known dietary toxicants but also of dietary antioxidants assumed to be beneficial to human health are much more complicated than expected in the past. The research focus shifts from damage and protection of single molecules to more sophisticated interference with the complex network of cellular regulation.