Conference: 2012 Biomolecular Interactions & Methods GRC & GRS to be held in Galveston, TX January 14-20,2012

该奖项是为了支持将于2012年1月15日至20日在德克萨斯州加尔维斯顿历史悠久的加尔韦斯酒店举行的戈登研究会议(GRC)，会议主题为“生物分子相互作用和方法”(BIM)。此外，第二届相关的戈登研究研讨会(GRS)将于前一个周末(2012年1月14日至15日)在同一地点举行。2012年GRC/GRS将提供一个信息交流的国际论坛，该论坛将结合广泛的实验和理论方法，并促进原子和细胞水平之间的新联系，增强我们对完整的生物系统如何通过严格监管的相互作用来执行其复杂功能的理解。GRS是专门为鼓励和丰富年轻科学家而设计的。这次会议将为不同的科学家群体提供一个独特的机会，分享他们的想法，并讨论支撑从原子到生物的生物相互作用的最新研究，以推动定量生物学研究的前沿。智力优势：生物分子之间的动态相互作用是支配所有活着的有机体的细胞过程的基础。虽然分子生物学和遗传学方法确定了特定生物过程中的关键角色，但需要详细描述这些角色及其相互作用的时间，以深入了解它们在细胞中的功能角色。目前的方法现在能够提供孤立的生物相互作用的时间分辨视图。此外，已经建立了理论框架，不仅可以对特定的分子识别事件进行建模，还可以对相互作用的分子系统进行建模，使我们非常接近对细胞结果的预测。这次会议将聚集一个高度跨学科的科学家小组，他们的专业知识从计算机模拟到包括单分子、生物化学、生物物理学、活细胞成像和完整系统研究在内的实验，以确定研究的前沿，以预测单个分子水平的事件必须如何与整个细胞过程相关联。更广泛的影响。GRC组织坚定地致力于支持科学多样性。对于2012年GRC BIM，50%的正式领导职位由女性担任：四名会议组织者中的两名，八名讨论负责人中的四名，以及两名GRS/GRC主旨演讲者中的一名女性。我们已经确认了一位拉美裔科学家(约翰·霍普金斯大学的伯特兰·加西亚-莫雷诺)。和一位非洲裔美国科学家(阿肯色州大学的保罗·亚当斯)作为演讲者。在建议增加的GRC发言者中，25%是妇女，7%是代表性不足的少数族裔科学家，预计妇女和少数族裔将作为高知名度的发言者参加本次会议。GRS是由研究生和博士后组织的，致力于培训和指导这些年轻科学家。GRC和GRS计划的项目是高度跨学科的，主要目标是促进不同科学领域的概念和思想的交流，以打破障碍并产生新的研究方向。这次会议和研讨会得到了生物科学局分子和细胞生物科学部生物分子动力学、结构和功能集群的支持。

AbstractThis award is in support of a Gordon Research Conference (GRC) on "Biomolecular Interactions and Methods" (BIM) will be held on January 15th - 20th, 2012 at the historic Hotel Galvez in Galveston, Texas. In addition, the second associated Gordon Research Seminar (GRS) will be held at the same location on the preceding weekend (January 14th - 15th, 2012). The 2012 GRC/GRS will provide an international forum for information exchange that will incorporate a broad array of both experimental and theoretical approaches and catalyze new connections between the atomic and cellular levels, enhancing our understanding of how intact biological systems carry out their complex functions through tightly regulated interactions. The GRS is specifically designed to encourage and enrich young scientists. This meeting will provide a unique opportunity for a diverse group of scientists to share their ideas and discuss the latest research that underpins biological interactions, from atoms to organisms, to push the frontiers of quantitative biological research. Intellectual merit: Dynamic interactions between biological molecules underlie the cellular processes that govern all living organisms. While molecular biology and genetics approaches identify key players in a given biological process, the detailed characterization of these players and the timing of their interactions is required to develop an in-depth understanding of their functional roles in the cell. Current methods are now capable of providing a time-resolved view of isolated biological interactions. Moreover, theoretical frameworks have been established to model not only specific molecular recognition events, but also systems of interacting molecules, bringing us tantalizingly closer to the prediction of cellular outcomes. This meeting will gather together a highly interdisciplinary group of scientists, with expertise ranging from computer simulation to experiments including single molecules, biochemistry, biophysics, live cell imaging and studies of intact systems, in order to define the frontier of research to predict how events at the individual molecule level must be correlated to overall cellular processes. Broader Impact. The GRC organization has a strong commitment to supporting diversity in the sciences. For the 2012 GRC BIM, 50% of the formal leadership roles are being held by women: two of the four meeting organizers, four of the eight Discussion Leaders, and one of the two GRS /GRC keynote speakers are women. We have identified one Hispanic scientist (Bertrand Garcia-Moreno, Johns Hopkins U.) and one African American scientist (Paul Adams, U. Arkansas) as speakers. Of the proposed additional GRC speakers, 25% are women and 7% are underrepresented minority scientists, for a total of anticipated participation of women and minorities as highly visible speakers at this meeting. The GRS is organized by and for graduate students and postdocs, and is dedicated to the training and mentoring of these young scientists. The GRC and GRS planned programs are highly interdisciplinary, with a key objective of fostering exchange of concepts and ideas across diverse areas of science to break down barriers and generate novel directions of investigation.This conference and seminar are supported by the Biomolecular Dynamics, Structure and Function Cluster, in the Division of Molecular and Cellular Biosciences, in the Directorate for Biological Sciences.