An Advanced Laboratory in Biological Physics

生物物理先进实验室

基本信息

  • 批准号:
    1139906
  • 负责人:
  • 金额:
    $ 14.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-01-01 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

Research in the life sciences is becoming increasingly interdisciplinary. More biological and biomedical scientists are using new tools and techniques that have been developed by physical scientists, mathematicians, and engineers. At the same time, growing numbers of physicists and engineers are seeking careers in biological and biomedical fields. Recognizing these trends, national panels have urged that the training of the next generation of life scientists should much more closely integrate the biological sciences with the physical sciences and mathematics. This project directly serves to enhance the integration of physics and biology in undergraduate education by developing and testing advanced physics laboratory experiments involving biological physics. Four new student experiments that explore biological applications of experimental physics are being designed and implemented. These labs train undergraduate students in the use of state-of-the-art physics techniques to measure and probe the properties of individual biological molecules and individual living cells. Experiments include measuring the size of individual DNA molecules by observing Brownian motion, probing the elasticity of DNA molecules through gel electrophoresis, using fluorescence correlations to measure the strength of interactions between biomolecules, and building "laser tweezers" to gauge the forces generated by a swimming bacterium. The project envisions a wide range of institutions (from research universities to small colleges) being able to provide similar training experiences to their students, and instructional materials are being written that can be shared with physics faculty and staff at other institutions. Such materials enhance the dissemination of these experimental experiences to the broader physics teaching community through the American Association of Physics Teachers (AAPT) and the National Science Digital Library (NSDL), and through presentations at national and regional professional meetings. The broader impact of this work is also enhanced by the training of faculty members from other institutions through open-house laboratory immersions, coordinated through the national Advanced Laboratory Physics Association (ALPhA). The educational impact of the experiments is being determined by a formal evaluation program using both a Student Assessment of Learning Gains (SALG) instrument and student interviews.
生命科学的研究正变得越来越跨学科。越来越多的生物和生物医学科学家正在使用由物理科学家、数学家和工程师开发的新工具和技术。与此同时,越来越多的物理学家和工程师正在寻求生物和生物医学领域的职业。认识到这些趋势,国家小组敦促下一代生命科学家的培训应该更紧密地将生物科学与物理科学和数学结合起来。本项目通过开发和测试涉及生物物理的高等物理实验室实验,直接服务于促进物理与生物在本科教育中的融合。正在设计和实施四个新的学生实验,探索实验物理的生物学应用。这些实验室训练本科生使用最先进的物理技术来测量和探测单个生物分子和单个活细胞的特性。实验包括通过观察布朗运动来测量单个DNA分子的大小,通过凝胶电泳探测DNA分子的弹性,使用荧光相关性来测量生物分子之间相互作用的强度,以及构建“激光镊子”来测量游泳细菌产生的力。该项目设想广泛的机构(从研究型大学到小型学院)能够为他们的学生提供类似的培训经验,并且正在编写教学材料,可以与其他机构的物理教职员工共享。这些材料通过美国物理教师协会(AAPT)和国家科学数字图书馆(NSDL),以及通过在国家和地区专业会议上的演讲,加强了这些实验经验在更广泛的物理教学界的传播。通过国家高级实验室物理协会(ALPhA)的协调,通过开放的实验室体验对来自其他机构的教职员工进行培训,也增强了这项工作的广泛影响。实验的教育影响是通过使用学生学习收益评估(SALG)工具和学生访谈的正式评估程序来确定的。

项目成果

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Stephen Hagen其他文献

Cover crops, crop insurance losses, and resilience to extreme weather events
覆盖作物、作物保险损失和应对极端天气事件的能力

Stephen Hagen的其他文献

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{{ truncateString('Stephen Hagen', 18)}}的其他基金

Collaborative Research: Evolution of information processing in the Vibrio fischeri pheromone-signaling network
合作研究:费氏弧菌信息素信号网络中信息处理的演变
  • 批准号:
    1715981
  • 财政年份:
    2017
  • 资助金额:
    $ 14.05万
  • 项目类别:
    Standard Grant
CAREER: Understanding Protein Folding Dynamics in the Ultra-Fast Limit
职业:了解超快极限下的蛋白质折叠动力学
  • 批准号:
    0347124
  • 财政年份:
    2004
  • 资助金额:
    $ 14.05万
  • 项目类别:
    Continuing grant
Dynamics of Polypeptide Diffusion and Collapse
多肽扩散和塌陷的动力学
  • 批准号:
    0077907
  • 财政年份:
    2000
  • 资助金额:
    $ 14.05万
  • 项目类别:
    Continuing grant

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    10552967
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Meeting: The Developmental Biology of the Sea Urchin XXIV, The Marine Biological Laboratory, Woods Hole, MA, April 5-9, 2017
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