NMR Investigations of the Self Organization and Dynamics of Amyloid Protein Fibrils (A06)

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The goal of the project is to understand the fundamental basis of protein fibril formation. We study the different stages of the self-organization process and the structure and dynamics of the protein by NMR methods. To this end, we systematically alter well-known molecular contacts of amyloid β (Aβ40) peptides by introducing specific physical fields into these positions or modifying larger segments of the amyloid structure. These modifications act as internal constraints on the structure forming process.